The hidden dangers of traffic safety risks have increased since Spring Festival travel rush, and the Ministry of Public Security has issued safety tips.

  Xinhua News Agency, Beijing, January 15th (Reporter Ren Qinqin) Since the launch of the Spring Festival travel rush in 2023, the traffic flow of various places, especially the trunk roads, has greatly increased, and the traffic safety risks have also increased. The Ministry of Public Security reminds drivers that safety is the shortest way home. When driving, they must pay attention to traffic safety, concentrate on driving, and rest in time if they are tired.

  At present, it is at the peak of returning home before the holiday, and the traffic flow is large. Recently, a road traffic accident occurred in Ningxia, Yunnan, Fujian, Anhui, Chongqing, Shaanxi and other places, which killed more than three people.

  The Ministry of Public Security reminds drivers to know the traffic conditions and weather forecast in advance, plan the travel route and travel time reasonably, avoid congested road sections and bad weather periods such as fog and snow as much as possible, and pay attention to reducing the speed and keeping a good distance in case of bad weather.

  Drivers should carefully assess their health status, and if they feel unwell, they must suspend driving. When driving, you should concentrate, don’t overspeed, don’t drive distracted, don’t answer your cell phone, and pick up things. In case of congestion, the slow-moving sections should be lined up in turn, and there should be no congestion to avoid increasing congestion due to disorder and increased scraping. When driving a vehicle, all personnel should fasten their seat belts, the continuous driving time should not exceed 4 hours, and the stopping time should not be less than 20 minutes each time. If you feel tired and sleepy during driving, you should stop and rest in time.

  During the gathering of relatives and friends during the Spring Festival, always remember "don’t drink when driving, don’t drive when drinking", and don’t drive after drinking. Drivers of buses, trucks and other operating vehicles and transport enterprises should not only pay attention to efficiency, but also ignore safety. They should not drive over speed, overload, overcrowding or fatigue, so as to prevent accidents caused by mass casualties.

The escort rider care and support team was awarded the "High-energy Team" in Harvard Business Review.

 On August 18th, the second "High-energy Team Award" sponsored by Harvard Business Review and FESCO was officially announced. After eight months’ selection, the "Care and Protection Team of Flash Company" stood out from more than 100 participating enterprise teams and won the grand prize of the High-energy Team Award.

"High-energy Team Award" is a heavy award for organizational management, aiming at finding and commending those high-energy teams that are constantly evolving and surpassing themselves in the organization, and exploring new methods of enterprise management in the future. In order to let more excellent teams be seen and valued, provide learning and reference experience for enterprise organization and management, and produce greater social value. This year’s "High-Energy Team Award" was reviewed from six dimensions: innovation ability, strategic execution ability, agile response ability, performance influence ability, team attraction ability and team resilience, resulting in three full-court awards and 30 individual awards.

As a pioneer in the field of one-hour instant delivery service in the same city, Flash Delivery provides users with one-to-one express delivery service in the same city for 7×24 hours, helping users solve various "urgent, busy, lazy and difficult" problems.

"Emergency rescue" is a common situation encountered by couriers. The existence of couriers greatly relieves people’s anxiety and makes people’s work and life more calm and beautiful. Once a company boss found that he forgot to bring important documents when he was approaching the meeting place, and asked his assistant to deliver them by car urgently. However, due to the traffic jam, the assistant could not arrive at the specified time. In desperation, he parked his car on the side of the road, called for a flash delivery, and repeatedly told him to deliver them on time, otherwise he would be criticized. With the flexible advantages of electric vehicles, the flasher delivers the documents to the recipients within the specified time, so that the meeting can proceed smoothly. Afterwards, the assistant was praised by the boss for his flexibility.

Up to now, the number of licensing flashers on the flash platform has exceeded 2 million, and the number of service users has exceeded 100 million. The rider is the transmitter and practitioner of the flash value. Flash has been striving to build a win-win ecology with the rider, so that they can take orders comfortably, safely and happily to help more users. Therefore, the "care and protection team of the flash driver" has successively launched a number of care measures, such as rider safety protection, reducing the cost of taking orders, improving the experience of taking orders, promoting the career of riders, caring for riders, and improving the service of riders’ cultural life.

In terms of rider protection, flash always puts personal safety in the first place, and occasionally provides traffic safety training for flash drivers in conjunction with local traffic control departments throughout the country, always reminding flash drivers to regulate their travel and travel safely; In special periods such as high temperature, severe cold and disasters, the "Escort Care and Support Team" will provide all kinds of materials for the escorting staff free of charge to protect the rights and interests of riders.

In terms of career development, in order to provide a venue for emotional communication for couriers, since 2022, Flash has set up a "home for riders" in many cities across the country to provide them with comprehensive operation and service guarantee places such as induction training, communication, problem solving, coffee breaks and offline activities; At the same time, Flash-forward launched activities such as "Gold Medal Lecturer" and "Rider Communication Camp" internally, and invited excellent riders to share the skills of taking orders for new riders, so as to improve the high-quality service ability of flash-forward, thus helping users better and solving practical difficulties for users. And open a career promotion channel, excellent flashers can be hired as formal employees of the company.

In terms of family care, Flash has launched the "College Entrance Examination Aid Program". Since 2020, it has provided free tuition for flash attendants or their children who have been admitted to excellent colleges and universities for one year, which not only rewards their excellent academic performance, but also helps flash attendants to reduce their family financial pressure.

"Deliver with kindness" is the service concept of flash delivery. For a long time, flash delivery has promoted the cultural construction of "kindness and altruism" among riders and established a "love reward plan", which has also made the platform care for riders and the riders give back to the society. In the future, the "Escort Care and Support Team" will continue to work from the aspects of order taking mechanism, income security, training and learning, and health security to provide more convenience for riders.

Ten Typical Cases of Intellectual Property Protection by Procuratorial Organs in China in 2013

  editorial comment/note On April 22, the Supreme People’s Procuratorate held a press conference to introduce to the media the situation of procuratorial organs’ strengthening judicial protection of intellectual property rights in 2013, and announced ten typical cases of procuratorial organs’ protection of intellectual property rights in 2013. Among the 10 selected cases, there are 5 cases of copyright infringement, 3 cases of trademark infringement and 2 cases of trade secret infringement; There are 8 criminal cases, 1 civil protest case and 1 administrative protest case, involving many knowledge-based economic fields such as industrial technology, e-commerce and software information. In order to focus on the new progress made in the judicial protection of intellectual property rights by procuratorial organs and provide guidance for the correct application of laws in handling intellectual property cases in various places, this newspaper has compiled and published these ten typical cases, so please pay attention.

  Typical case 1

  The case of four people, including Yibo Company, Ward Company and Yu Zhihong, infringing trade secrets.

  Case fact: Guangdong Zhuhai Saina Printing Technology Co., Ltd. (hereinafter referred to as "Saina Company") was established in 2006. It is an innovative enterprise integrating R&D, manufacturing and sales of laser printers and other printing consumables. It has more than 330 proprietary technologies at home and abroad, and has won the title of "Global Leading Enterprise in General Laser Printing Consumables Industry", "2011 Forbes China Potential Enterprise" and "Guangdong Famous Brand Enterprise".

  From January to March, 2011, Yu Zhihong, the former executive deputy general manager of Seine Company, and others imitated the business model of Seine Company, and established Jiangxi Yibo Electronic Technology Co., Ltd. (hereinafter referred to as Yibo Company) and Guangdong Zhongshan Ward Company (hereinafter referred to as Ward Company), and established three companies dedicated to selling Yibo Company’s products in Hong Kong, the United States and Europe. Subsequently, Yu Zhihong joined Luo Shihe, former sales director of Seine Company, Li Yinghong, former product manager and Xiao Wenjuan, former product sales manager, to work in Yibo Company and Ward Company without going through the resignation formalities with Seine Company. When the four people left their jobs, they took away the business information of Seine’s customers privately, and through the analysis of the information, they formulated a targeted sales strategy and price system, and then dumped the products to Seine’s customers. The behavior of Yu Zhihong and others maliciously competing for customers of Seine Company has caused huge economic losses to the company, caused great difficulties in its production and operation, and caused the company to be on the verge of bankruptcy.

  Proceedings: On January 28, 2012, the public security organ applied to the procuratorial organ for approval to arrest the persons involved on suspicion of infringing trade secrets. On February 3 of the same year, Zhuhai City Procuratorate made a decision to approve the arrest; On June 6th, the case was transferred for review and prosecution. On July 9, 2013, Zhuhai Intermediate People’s Court made a second-instance judgment, and sentenced Yibo Company to a fine of 21.4 million yuan for the crime of infringing trade secrets; Ward Company fined 14.2 million yuan; Yu Zhihong and other four people were sentenced to fixed-term imprisonment ranging from six to two years, and each was fined from 1 million yuan to 100,000 yuan.

  Comments: This case was undertaken by the Intellectual Property Office of High-tech Zone of Zhuhai Procuratorate, Guangdong Province, the first independent intellectual property office in China. In view of the complexity of the case, inter-provincial crimes, many people involved, strong professionalism, and difficulties in investigation and evidence collection, the procuratorial organs promptly intervened and actively urged the public security organs to file a case for investigation and put forward targeted suggestions to guide the investigation. At the same time, they followed up the investigation activities throughout the process, so that the case could be successfully handled.

  The typical significance lies in the high amount of crimes, great harm and wide influence in this case. The successful handling of the case fully reflects the institutional and institutional advantages of the specialized handling mode of intellectual property cases of procuratorial organs, as well as the ability and determination of procuratorial organs to dare to supervise and be good at supervising major difficult and complicated cases and strictly perform their legal supervision duties according to law.

  Typical case 2

  Eight people including Ruichuang Company and Han Meng infringed copyright.

  Case fact: Since 2008, Han Meng, general manager and Han Hongchang, deputy general manager of Shanghai Ruichuang Network Technology Co., Ltd. (hereinafter referred to as "Ruichuang Company"), in order to promote the company’s 2345 navigation website, instructed employees Qian Wuxing, Luo Hua and others to make pirated operating systems such as "Radish Home" by illegally copying Microsoft’s Win-dows operating system software. And bind and integrate malicious code in pirated software, and increase the company’s website views, attract paid advertisements, load paid links, and gain huge illegal benefits by publishing download links and hiring people to distribute pirated CDs offline for free. After auditing, the 2345 website earned a total operating income of 23.87 million yuan for Ruichuang Company.

  Proceedings: In March 2011, Shanghai Public Security Bureau filed a case to investigate the case. Designated by the Municipal Procuratorate, the Procuratorate of Pudong New Area sent personnel to intervene in the investigation and guide evidence collection in advance. On June 4, 2012, the case was prosecuted. On February 4, 2013, the court in Pudong New Area fined Ruichuang Company 10 million yuan for copyright infringement, and sentenced Han Meng, Han Hongchang and others to prison terms ranging from three years to one year and six months, and each fined 1 million yuan to 100,000 yuan. This judgment is effective.

  Comments: The infringement in this case lasted for three years, involving 286 cities in 29 provinces (autonomous regions and municipalities directly under the Central Government), and the amount of infringing software and illegal business was extremely huge. The injured unit (Microsoft) had filed a civil compensation claim of 100 million yuan in this case.

  The typical significance is that the procuratorial organs did not handle the case, but extended the effect of handling the case. They not only actively carried out court education to urge the infringer to sincerely repent, but also tried their best to repair social relations and completely resolve the contradictions between the parties. Eight defendants bowed and apologized to the injured unit in court. After the trial, the defendant unit issued an apology statement through official website, and compensated the injured unit for 36 million yuan, obtaining the understanding of the injured unit. After the case was pronounced, the injured unit made a special trip to the procuratorate to express appreciation and gratitude to the judicial organs in China for their efforts and meticulous work style in cracking down on infringement and piracy.

  Typical case 3

  Jiafei Company sells counterfeit registered trademarks.

  Case fact: From October 2011 to February 2012, Gong Yingbing, the general manager of Chongqing Jiafei Trading Co., Ltd. (hereinafter referred to as "Jiafei Company") and Wang Ziquan, the legal representative of the company, conspired to buy Feitian Moutai with a registered trademark of Kweichow Moutai for profit. The latter two organized company personnel to sell the above-mentioned fake wine at the sales business meeting. Up to the time of the incident, Jiafei Company has sold 240 bottles of fake Feitian Moutai, with a total sales amount of 270,360 yuan; 128 bottles of fake Feitian Moutai that have not been sold (calculated by the average sold price, the value is 144,192 yuan).

  Proceedings: On March 15th, 2012, the Procuratorate of Yunyang County in Chongqing issued a procuratorial proposal to the County Bureau of Commerce, requesting that the clue of Jiafei Company’s case of selling fake Kweichow Moutai be transferred to the County Public Security Bureau. The county bureau of commerce then handed over the case clues to the public security organs. On March 28th, the county public security bureau filed a case for investigation on the crime of allegedly selling goods with counterfeit registered trademarks. After filing the case, the county procuratorate continued to track the investigation of the case and guided the county public security bureau to dig out the case of Xiao Moumou in Guizhou manufacturing and selling counterfeit Moutai. After obtaining the clue of Xiao Moumou’s case, the Ministry of Public Security directed Chongqing, Guizhou, Sichuan and other places to act in a unified way, and destroyed the dens for manufacturing and selling counterfeit Moutai in one fell swoop. On April 25, 2013, the county public security bureau requested the county procuratorate to approve the arrest of Wang Ziquan and Gong Yingbing. On April 28th, the procuratorate made a decision to approve the arrest. On July 10th, the case was prosecuted. After the second trial of the case, the court finally sentenced Jiafei Company to a fine of 200,000 yuan for selling goods with counterfeit registered trademarks, sentenced Wang Ziquan and Gong Yingbing to two years and six months in prison, and each fined 136,000 yuan. This judgment is effective.

  Comments: This is a case that successfully supervised the transfer of suspected criminal cases by administrative law enforcement agencies relying on the working mechanism of linking administrative law enforcement with criminal justice.

  The typical significance is that the procuratorial organs are not satisfied with supervising the transfer of cases of selling fake liquor, but continue to track the investigation of cases and guide the public security organs to dig out a major case of manufacturing and selling fake Moutai liquor across provinces. After the local public security organs reported to the Ministry of Public Security, the Ministry of Public Security directed the public security organs in Chongqing, Guizhou, Sichuan and other places to act in a unified way, destroying an inter-provincial source of manufacturing and selling fake wine in one fell swoop and expanding the effect of handling cases.

  Typical case 4

  Li Haitao and other three people violated trade secrets.

  Case fact: In August 2006, Li Haitao resigned from Qilu Pharmaceutical Co., Ltd. Before and after his resignation, Li Haitao obtained the production technology of ceftazidime and other drugs by illegal means. In August 2008, Li Haitao purchased the production process of cefminox from Jin Chao, an employee of Qilu Antie Pharmaceutical Co., Ltd. (hereinafter referred to as Qilu Antie Company). From the end of 2006 to 2010, Li Haitao illegally disclosed the production process of five drugs, including ceftazidime, to Zhao Yuxin, assistant director of Harbin Pharmaceutical Group Pharmaceutical Factory, and allowed them to be used. Knowing that the above-mentioned pharmaceutical production process was illegally obtained, Zhao Yuxin still carried out process test, technical reserve and process improvement in the General Pharmaceutical Factory of Harbin Pharmaceutical Group. It was identified that Li Haitao and Zhao Yuxin illegally disclosed and obtained ceftazidime and other five production processes, which caused economic losses of more than 2.46 million yuan for Qilu Antie Company, and Jin Chao’s illegal disclosure of cefminox production process caused economic losses of more than 1.14 million yuan for Qilu Antie Company. After the incident, Li Haitao compensated Qilu Antu Company for its economic loss of 600,000 yuan, and Jin Chao compensated Qilu Antu Company for its economic loss of 10,000 yuan.

  Proceedings: On October 27th, 2011, Licheng Branch of Ji ‘nan Public Security Bureau applied to the procuratorate for approval of the arrest of Li Haitao, Jin Chao and Zhao Yuxin on suspicion of illegally obtaining computer information system data. After examination, the procuratorial organ made a decision to approve the arrest of Li Haitao, Jin Chao and Zhao Yuxin on suspicion of infringing trade secrets. On June 8, 2013, Jinan Intermediate People’s Court made a second-instance judgment, and found Li Haitao, Jin Chao and Zhao Yuxin guilty of infringing trade secrets, and sentenced them to fixed-term imprisonment ranging from two years and six months to one year and three months respectively, and fined them.

  Comments: The victim Qilu Antie Company is a subsidiary of Qilu Pharmaceutical Factory, a well-known domestic pharmaceutical company, and the largest professional manufacturer of cephalosporin APIs in China. The case is complicated, professional, long in time span and difficult to obtain evidence.

  The typical significance is that in order to find out the facts of the case, the procuratorate not only carefully checked the evidence, but also detailed the outline of supplementary investigation, guiding the public security organs to collect, retrieve and fix the evidence, which laid a solid foundation for the successful handling of the case. In particular, the accurate identification of the nature of the case by the procuratorate has enabled the public security organs to adjust the direction of investigation and evidence collection in time and ensure the quality and effectiveness of cracking down on crimes.

  Typical case 5

  Case of copyright infringement by 19 people including Xinfeishi Company and Zheng Wuyue.

  Case fact: In December 2011, Zheng Wuyue and Zhang Xiulan contacted Guangdong Xinfeishi Laser Technology Co., Ltd. (hereinafter referred to as "Xinfeishi Company", a formal enterprise producing audio-visual products in Guangzhou, Guangdong Province) through Zhang Shaobo to produce 4,000 pirated CDs of the movie "Wolf Smoke Everywhere". Xinfeishi Company produced the pirated CD for Zhang Shaobo without the permission of the copyright owner Zhejiang Hengdian Film and Television Production Co., Ltd. Packed by Zheng Wuyue and Zhang Xiulan, the CDs were sold all over the country. After the incident, the public security organs seized more than 150,000 pirated CDs, master discs, disc cores and other illegal audio-visual products from Zheng Wuyue, Zhang Xiulan, Zhang Shaobo and their offline retailers, and frozen more than 3 million yuan in the accounts of the registered personnel.

  Litigation: The film Wolf Smoke Everywhere was shot by Zhejiang Hengdian Film and Television Production Co., Ltd. with an investment of 42 million yuan. After it was released on December 2, 2011, it was discovered that it was pirated on December 5. On December 6th, the Public Security Bureau of Dongyang City, Zhejiang Province filed an investigation on the copyright infringement of the movie "Wolf Smoke Everywhere", and arrested 19 pirated CD wholesalers Zhu Guoqing, Zhang Xiulan and Tang Shuigen, pirated CD retailer Pan Juzeng and their employees, and the staff of the pirated CD manufacturer Xinfeishi Company, destroyed 5 pirated CD dens and seized 4 pirated CD production lines. Dongyang City Procuratorate made a decision to approve the arrest of 17 of them on suspicion of copyright infringement (two others were released on bail pending trial). After the case was transferred for review and prosecution, the procuratorial organ additionally identified the unit criminal behavior of Xinfeishi Company. In September 2013, Dongyang City Court held a hearing on the case and adopted all the public prosecution opinions of the procuratorate, and sentenced the defendant unit to a fine of 2 million yuan for copyright infringement; Nineteen people including Zheng Wuyue, Zhang Shaobo and Zhang Xiulan were sentenced to fixed-term imprisonment ranging from four years and six months to ten months, and each was fined from 1 million yuan to 20,000 yuan.

  Comments: This case is jointly supervised by the Ministry of Public Security and the Ministry of Culture, and it is a case that seriously infringes on the development of local film and television culture industry. The case involves a wide range, many people, and the criminal links are complicated, which has attracted much attention from the society.

  The typical significance lies in that the procuratorial organs fully performed their procuratorial functions, intervened in investigation in time, guided evidence collection according to law, successfully prosecuted unit crimes, and urged the public security organs to completely destroy several dens selling pirated CDs all over the country, and urged some people involved in the case to surrender themselves. At the same time, the procuratorial organs also actively recovered more than 25 million yuan in economic losses for the injured enterprises.

  Typical case 6

  Zhu Jianjun infringed copyright and Luo Mingyong and other 13 people sold infringing copies.

  Fact of the case: In October 2011, Luo Mingyong, Ning Chuanyin and others conspired to set up a gang that illegally copied CFA textbooks with unified supply, unified purchase price, unified sales price and unified dividend sales (note: CFA is the abbreviation of "Certified Financial Analyst" or "Chartered Financial Analyst" and is the internationally recognized highest certificate of financial and securities industry) in order to gain illegal benefits. As of the time of the incident, Zhu Jianjun sold more than 20,000 sets of CFA textbooks illegally printed to Luo Mingyong and others, with a total sales amount of more than 1 million yuan. From January to March, 2012, the gang’s illegal income from selling illegally copied CFA textbooks totaled more than 1.3 million yuan. In July 2012, the public security organs seized 25,000 pirated CFA textbooks in the warehouse rented by Luo Mingyong.

  In addition, it was found that Ning Chuanyin illegally copied and sold ACCA teaching materials in collaboration with others without the authorization of the obligee (note: ACCA refers to "international certified public accountant" and is one of the most authoritative certificates in the field of accounting and finance in the world). Up to the time of the crime, Ning Chuanyin had sold 100 Yu Ben of illegally copied ACCA textbooks, making an illegal profit of more than 2,500 yuan. The public security organs seized 521 illegally copied ACCA textbooks that Ning Chuanyin had not yet sold.

  Proceedings: On June 8, 2012, Yangpu Branch of Shanghai Public Security Bureau filed a case for investigation. On August 22 and September 19, 2012, 14 people involved in the case were arrested with the approval of Yangpu District Procuratorate. On November 22nd, the case was prosecuted by Yangpu District Procuratorate. On February 1, 2013, Yangpu District Court sentenced Zhu Jianjun to three years and eight months in prison for copyright infringement and fined him 150,000 yuan. Thirteen people, including Luo Mingyong, were sentenced to fixed-term imprisonment ranging from one year and six months to eight months for selling infringing copies, and each was fined ranging from 70,000 yuan to 35,000 yuan. This judgment is effective.

  Comments: This case is the largest pirated textbook case seized in Shanghai in recent years. Fourteen people, including Zhu Jianjun and Luo Mingyong, formed a gang with unified supply, unified purchase price, unified selling price and unified dividends to illegally copy the teaching materials of certified financial analysts and international certified accountants. There are many people involved in the gang, and the division of labor among members is strict and the relationship is complex, so it is very difficult to obtain evidence.

  The typical significance lies in that, in view of the fact that intellectual property crimes are frequently occurring, the criminal methods are constantly changing, and the criminals’ ability to deal with criminal attacks is also increasing, some local procuratorial organs have set up professional teams or specialized agencies to strengthen the handling of such cases. During the handling of this case, the Yangpu District Procuratorate of Shanghai made full use of the advantages of the professional case handling mechanism, put forward opinions on the fixation of electronic evidence and the reinforcement of offline evidence, actively guided the investigation, and laid a solid foundation for the successful handling of the case.

  Typical case 7

  Zhongfu Electronics Company and Li Qiang case of copyright infringement.

  Case fact: In July 2011, the Education and Sports Bureau of pingdu city, Shandong Province invited public bidding to purchase computers, and Qingdao Zhongfu Information Industry Co., Ltd. (hereinafter referred to as "Zhongfu Information Company") won the bid. In September 2011, pingdu city Education and Sports Bureau signed a sales contract with Zhongfu Information Company, stipulating that Zhongfu Information Company was responsible for supplying goods and installing commonly used software free of charge. On September 20, 2011, Zhongfu Information Company entrusted Qingdao Zhongfu Electronics Co., Ltd. (hereinafter referred to as "Zhongfu Electronics Company") for installation. Li Qiang, the legal representative of Zhongfu Electronics Company, downloaded WindowsXP operating software and office(2003) office software from the Internet without the consent of Microsoft (China) Co., Ltd., and hired others to copy and install the downloaded software on 1076 computers. According to the appraisal, the WindowsXP operating software and office(2003) office software installed in Li Qiang are highly similar to those of Microsoft’s related genuine software files, accounting for more than 89% of them with the same binary, and the operating interface and software functions are the same.

  Proceedings: On March 11th, 2013, pingdu city Public Security Bureau transferred Li Qiang for review and prosecution for copyright infringement. On March 27th, pingdu city Procuratorate filed a public prosecution in this case. On May 2, the pingdu city court made a judgment, finding Zhongfu Electronics Company guilty of copyright infringement and fined 150,000 yuan; Li Qiang was convicted of copyright infringement and sentenced to two years’ imprisonment, suspended for two years, and fined 50,000 yuan. This judgment is effective.

  Comments: This case is a new type of copyright infringement case using pre-installed computer pirated software for profit.

  The typical significance is that this case is the first case in which a computer seller in China was sentenced for pre-installing pirated software. The successful handling of the case has set a precedent for criminal crackdown on pre-installed pirated software on hard disks. The procuratorial organ’s public prosecution opinion on determining the crime of copyright infringement by the number of pre-installed pirated software was finally adopted by the judicial organ, which provided a reference for investigating and punishing similar cases in the future. After the case was reported by domestic and foreign media, it received extensive positive comments.
  Typical case 8

  Xiao Zonghua’s case of counterfeiting registered trademarks and Chen Yuejiao’s case of selling counterfeit registered trademarks.

  Case fact: From 2010 to 2012, Taiwanese businessman Xiao Zonghua instructed others to organize a number of workers in Shantou City, Guangdong Province to produce counterfeit black sugar lollipops, and sold them to Chen Yuejiao and others, with a cumulative sales of more than 1.17 million yuan. Up to the time of the incident, Chen Yuejiao has purchased 155 counterfeit "plain-handed flowers" brown sugar lollipops from Xiao Zonghua for sale at a price of more than 70,000 yuan.

  Proceedings: On September 8, 2012, Huli Branch of Xiamen Public Security Bureau filed an arrest with Siming District Procuratorate of Xiamen for the crime of selling goods with counterfeit registered trademarks, such as Xiao Zonghua and Chen Yuejiao. On September 14th, the District Procuratorate arrested Xiao Zonghua on suspicion of counterfeiting registered trademarks and arrested Chen Yuejiao on suspicion of selling goods with counterfeit registered trademarks. On June 26, 2013, the district procuratorate filed a public prosecution on this case. On September 20th of the same year, the District Court sentenced Xiao Zonghua to four years and six months’ imprisonment and fined him 600,000 yuan. Chen Yuejiao was sentenced to six months’ imprisonment and fined 40,000 yuan for the crime of selling goods with counterfeit registered trademarks. This judgment is effective.

  Comments: This case is a key case supervised by the Ministry of Public Security, involving Fujian, Guangdong, Taiwan Province and other provinces. The infringed trademark is a well-known trademark in Taiwan Province, and the main person involved is from Taiwan Province, which has a great social impact.

  The typical significance is that the qualitative opinions put forward by the procuratorial organs in handling cases are supported by the court’s judgment, and they also put forward corrective opinions on the irregular law enforcement in investigation activities, which has achieved good results in handling cases.

  Typical case 9

  Tianjin Meat Joint Factory v. Song Xiaoman (civil protest case of copyright dispute)

  Case fact: Tianjin Meat Joint Processing Factory (hereinafter referred to as "Tianjin Meat Joint Factory") is a large state-owned enterprise engaged in pig slaughtering and meat product production. On January 13th, 1995, the factory began to use the image propaganda products of "cartoon pig". In 1999, Tianjin Meat Joint Factory signed an advertising agency release contract with Tianjin Mutual Advertising Co., Ltd. (hereinafter referred to as "Mutual Advertising Company"), stipulating that Mutual Advertising Company would act as the advertising agency of the factory from May 8 to June 6 of that year, and use the image of "cartoon pig" in TV advertisements. On May 31st, the product advertisement published by Tianjin Meat Joint Factory in "Tonight’s Evening News" and the patent certificates for the design of "sausage packaging bag" and "label (assured meat store)" obtained by the factory all used the cartoon pig. Since then, "cartoon pig" graphics have been widely used in product packaging, specialty store plaques, product advertisements and product transport carriages by Tianjin Meat Factory.

  On April 7th, 2010, Song Xiaoman registered the cartoon pig as a trademark. On August 27th of the same year, Tianjin Meat Joint Factory filed an objection application with the Trademark Office of the State Administration for Industry and Commerce. On February 20, 2012, the Trademark Review and Adjudication Board of the State Administration for Industry and Commerce ruled that the disputed trademark was revoked.

  On July 30, 2010, Song Xiaoman filed an application with the National Copyright Administration, requesting that his work "Dragon Pig Lele" (i.e. "Cartoon Pig"), which was completed on March 25, 1998, be given to copyright registration. On September 2 of the same year, the National Copyright Administration issued a copyright registration certificate to him.

  Proceedings: On July 14th, 2011, Song Xiaoman appealed to the Heping District Court of Tianjin on the grounds that the advertisement of Tianjin Meat Joint Factory infringed its copyright, demanding that Tianjin Meat Joint Factory stop the infringement and compensate for the losses. On April 10, 2012, the District Court ruled that Song Xiaoman’s claim was rejected. Song Xiaoman refused to accept and appealed. On September 17th, Tianjin No.1 Intermediate People’s Court, after hearing the case, held that the first-instance judgment was wrongly applied by law and revised it. Tianjin Meat Factory refused to accept the complaint and filed a complaint with the procuratorate. After examination, the Tianjin Procuratorate found that the facts identified in the final judgment lacked evidence, and filed a protest on December 3, 2012. On October 16, 2013, Tianjin No.1 Intermediate People’s Court found that the image of "cartoon pig" used by Tianjin Meat Joint Factory was legal and did not constitute infringement. The retrial judgment revoked the original final judgment and rejected Song Xiaoman’s claim.

  Comments: The focus of the dispute between the two parties in this case is whether the use of trademark graphics infringes copyright. After protest, the procuratorial organ corrected the mistake of the original final judgment.

  The typical significance is that the handling of this case is directly related to the people’s trust in well-known food brands. Procuratorial organs perform their civil litigation supervision duties according to law, accurately identify the facts of the case, and the protest opinions are supported by the court’s retrial judgment, which protects the legitimate rights and interests of obligees, maintains the normal market order and promotes the brand building of well-known enterprises.

  Typical case 10

  Wang Liang and Lin Jie v. Wuhan Administration for Industry and Commerce (administrative protest case of administrative compulsory measures)

  Case fact: In August, 2005, Wuhan Administration for Industry and Commerce of Hubei Province (hereinafter referred to as "Wuhan Administration for Industry and Commerce") received a report from Shanxi Yabao Pharmaceutical Group Co., Ltd. (hereinafter referred to as "Yabao Company") that the "Ding Guibao Diarrhea Sticker" produced and sold by Wuhan Sanchu Technology Development Co., Ltd. (hereinafter referred to as "Sanchu Company") was suspected of infringing on the exclusive right of registered trademark of Yabao Company. After preliminary investigation, Wuhan Industrial and Commercial Bureau found that Sanchu Company’s behavior violated the relevant provisions of the Trademark Law and decided to file an investigation. On October 17th, 2005, Sanchu Company filed a trademark review application for the registered trademark "Ding Gui" with the Trademark Review and Adjudication Board of the State Administration for Industry and Commerce. On December 16, 2005, Wuhan Administration for Industry and Commerce lifted the compulsory seizure measures according to the relevant regulations of the State Administration for Industry and Commerce and after Sanchu Company provided a guarantee. On January 27, 2006, the Trademark Office of the State Administration for Industry and Commerce made the Reply on Issues Concerning the Trademark of "Ding Gui". On February 16th, 2006, according to the reply, Wuhan Administration for Industry and Commerce issued the Notice of Detaining Property, with Sanchu Company being suspected of producing and selling infringing goods. Sanchu Company refused to accept the decision and applied to Wuhan Municipal Government for administrative reconsideration. The reconsideration organ makes a reconsideration decision to maintain the original specific administrative act.

  Proceedings: On April 29th, 2006, Sanchu Company filed an administrative lawsuit in Jianghan District Court of Wuhan, requesting an order to cancel the Notice of Holding Property made by Wuhan Administration for Industry and Commerce on February 16th. On June 30th, the District Court ruled to suspend the lawsuit on the grounds that "the basic administrative act of the accused specific administrative act has been brought by the plaintiff, and the trial in this case must be based on the trial result". On June 11th, 2009, Sanchu Company was approved for cancellation. On December 14th, the shareholders of the original company, Wang Liang and Lin Jie, continued the lawsuit as successors of rights and obligations. On December 21st, the first-instance judgment of the District Court found that the evidence of compulsory seizure measures of the Municipal Administration for Industry and Commerce was insufficient and should be revoked according to law. The Municipal Administration for Industry and Commerce refused to accept the appeal. On October 25, 2010, Wuhan Intermediate People’s Court made a final judgment to uphold the original judgment. The Municipal Administration for Industry and Commerce refused to accept the final judgment, and filed a complaint with the Wuhan Procuratorate on December 22, 2011, requesting to cancel the judgment of the second instance and maintain the Notice of Detaining Property made by it. After examination, the Wuhan Municipal Procuratorate considered that the judgment of the second instance was wrong, so it submitted a protest to the Hubei Provincial Procuratorate on June 26, 2012. On January 8, 2013, the Provincial Procuratorate lodged a protest with the Provincial High Court. After accepting the protest, the Hubei Provincial High Court ordered the Wuhan Intermediate Court to retry. The Wuhan Intermediate People’s Court held that the reason for the protest by the procuratorial organ was established, and the original judgments of first instance and second instance were revoked.Reject the claims of Wang Liang and Lin Jie.

  Comments: One party in this case refuses to accept the administrative compulsory measures taken by the administrative department for industry and commerce against the property suspected of infringing the exclusive right to use trademarks, and brings an administrative lawsuit. First, the court of second instance ruled that the Industrial and Commercial Bureau lost the case. After the procuratorial organ protested according to law, the court changed the sentence after retrial.

  The typical significance is that this case happened in the field of drug supervision closely related to people’s lives, health and property safety, and the trademark brand involved enjoys a high reputation in China and has a great social impact. The procuratorial organs exercised the right of administrative protest in time according to law, which prompted the court to retry and change the judgment, and supported the administrative protection of the trademark exclusive right of the obligee by the administrative department for industry and commerce. (Manuscript Coordinator: Our reporter Xu Yingyan)

 

Behind the biggest child trafficking case in Sichuan: the way home AI helps

  background for news stories

  "internet plus Kidnapping" Retrieves Nearly 4,000 Missing Children

  In March 2010, the Supreme People’s Court, the Supreme People’s Procuratorate, the Ministry of Public Security and the Ministry of Justice jointly issued the Opinions on Punishing the Crime of Abducting and Trafficking Women and Children according to Law, which stipulates that if a child is reported missing or a woman who has reached the age of 14 but is under the age of 18 is reported missing, the public security organ shall immediately file a criminal case and promptly carry out investigation; If it does not belong to its own jurisdiction, it shall be promptly transferred to the public security organ with jurisdiction.

  "The Ministry of Public Security has never said that children can be missing for 24 hours before filing a case." Chen Shiqu said that if parents find their children missing, they should call 110 at the first time, and the police must immediately file a case and carry out investigation according to regulations. The Ministry of Public Security has previously made it clear that in all cases of child trafficking, the public security organs implement the "one long and three guarantees system", that is, the main leaders or competent leaders of the county and urban public security organs serve as the project leaders, and are responsible for the investigation of the case, the search and rescue of the trafficked persons, and the appeasement of the victim’s family.

  The reporter learned from the the State Council Inter-Ministerial Joint Conference Office and the Criminal Investigation Bureau of the Ministry of Public Security that the publicity campaign of "Caring for Children and Opposing Trafficking" was held in Beijing. In the three years since the emergency release platform "Reunion" of missing children information of the Ministry of Public Security was launched, a total of 3,978 pieces of missing children’s information were released, and 3,901 missing children were recovered, with a recovery rate of 98%.

  According to reports, in order to meet the requirements of the "internet plus abduction" era, the Ministry of Public Security has developed the "Reunion" system, an emergency release platform for missing children’s information, which was officially launched on May 15, 2016. Once the missing information of children is released, the platform can help the public security organs to push the missing information of children to a certain range around the missing place through new media and mobile application terminals in the first time, so that more people can obtain relevant information accurately and provide clues in time to help the public security organs solve the case as soon as possible. At present, many new media and mobile applications have been connected to the platform.

  Comprehensive Xinhua all-media headlines, People’s Public Security News, etc.

  For many years, the police have been tirelessly pursuing abducted children.

  Ten lost faces, gradually blurred in the years … …

  Look at AI’s meritorious service.

  "Not reconciled, if we can’t find a child, we can’t explain it to our parents. We can’t lose!" On July 3rd, on the 6th floor of the Criminal Investigation Bureau of Sichuan Provincial Public Security Department, a white board in the office of Jiang Xiaoling, director of the Anti-trafficking Department, was filled with names, and they intertwined to form a net.

  In the past few years, Sichuan abduction police have been "competing" with a child trafficking case. Wang Mouwen is the key to this case. This 63-year-old man is closely related to 13 cases of child abduction in several cities and counties in Sichuan in 2008, 2009, 2010 and 2014. The reporter learned from the Criminal Investigation Bureau of the Sichuan Provincial Public Security Department that the case was the biggest child abduction case in the process of abduction in Sichuan.

  In 2014, Wang Mouwen was arrested. Except for the three children who were abducted in that year, the search for the other 10 children has continued to this day. At present, there are still three children still looking for them.

  13

  Not One Less

  On that whiteboard, the names of four abducted children are lined up in a row, with their date of birth and the time and place where they lost. Below the name, the lines are intertwined, and the clue information is connected in series.

  "This is the first group of children we found before." Xiao-ling jiang pointed to the whiteboard and looked tired. She didn’t go to sleep until after 2 am for several days. I just flew back to Chengdu from Shenzhen the day before.

  There are too many things, there are still three children who have not been found, and they have to mediate the relationship between the children and the two families. Things didn’t go well. She bluntly said, "I have a good personality, but I still can’t help losing my temper."

  This is a search for people that has been going on for five years. Jiang Xiaoling secretly struggled. "I’m not willing. If I can’t find a child, I can’t tell my parents. We can’t lose!"

  Three children.

  Successfully rescued in the year of abduction.

  The suspect was arrested

  Time goes back to five years ago.

  On the evening of April 26th, 2014, a three-year-old child was abducted from Suining, Sichuan. In the surveillance screen, a man in dark underwear left with his child on a motorcycle. After more than two months of investigation, the police grasped the trace of the suspected man and issued a notice to Quanchuan to collect similar cases with the same modus operandi.

  According to local reports: on April 7 of that year, a 3-year-old child from Tongjiang, Bazhong was abducted; On June 25th of that year, a 3-year-old child was abducted in Yilong, Nanchong. The three cases were connected in series, the suspect Wang Mouwen was highlighted, and the general whereabouts of the abducted children were found out.

  On the evening of July 30, 2014, the arrest operation began. The police arrested Wang Mouwen in Qu County, Dazhou, and arrested some middlemen associated with Wang Mouwen in Guangdong. Three children abducted in September of that year were also successfully rescued.

  The case written by Wang Mouwen is not limited to this. In 2014, the construction of public security monitoring in all parts of Sichuan has matured. Through the comparison of massive video information, the police found that in two cases of children lost in the summer of 2009, Wang Mouwen appeared again. "He is not tall, about 1.6 meters. He drags his children away and leaves by motorcycle." Jiang Xiaoling said.

  The same suspect has committed crimes many times in a row, and Wang Mouwen is definitely not simple.

  10 children

  The suspect confessed that they were taken to Guangdong a few years ago.

  As the trial continued, shocking progress appeared — — Wang Mouwen confessed that in addition to the three cases in 2014, he also brought 10 children to Shantou, Guangdong Province in Sichuan for three consecutive years in 2008, 2009 and 2010.

  Soon, the case was listed as a case supervised by the Ministry of Public Security. In the view of Jiang Xiaoling, who has been engaged in abduction for many years, the case has undoubtedly become the largest child abduction case in Sichuan.

  We must find these 10 children.

  "For parents, even if they give everything, if they don’t find someone, then everything is meaningless." Compared with catching the suspect, a long-lasting war for finding people has just begun.

  Wang Mouwen is the only breakthrough. But it is not easy to pry his mouth open. Wang Mouwen either refused to provide information about the middleman to the police, or constantly retracted his confession, which brought great difficulties to finding people.

  At that time, the police escorted Wang Mouwen to Guangdong and asked him to identify the place where the child was sent. In the process, Wang Mouwen was vague. "It seems that it is, but it seems that it is not. The urban construction has changed too much." After a lap, the police got nothing.

  "He is a very cunning man, and it is difficult for you to find out the truth of his words." Jiang Xiaoling introduced that in 2015, Wang Mouwen was finally convicted and sentenced to 15 years in prison for his crimes in 2014 and is still serving his sentence.

  "But in any case, there must be hope!" The police did not give up.

  deadlock

  10 "fuzzy" faces

  After many years, it is difficult to find people by changing their faces.

  In 2015, the Sichuan police carried out an attack on the case. The police sent a task force to Shantou and other places in Guangdong again to explore the clues left by Wang Mouwen and continue to look for people. However, due to dialect barriers and unfamiliar environment, the work is extremely difficult. In addition to learning the bank transaction information left by Wang Mouwen, I got nothing.

  Jiang Xiaoling said that the 10 abducted children involved were all under four years old at the time of the crime, and the youngest was only a 100-day-old baby. Children’s ability to remember stories is poor, and they can hardly remember the case. Moreover, they are in the stage of language learning, and their accents will change in just a few months. The police who participated in the rescue of three abducted children in 2014 said that when they were found in Guangdong, only in the past five months, the children had spoken fluent Chaoshan dialect, and their biological parents’ impressions were blurred.

  One road is impassable, so change to another. In 2016, the task force found Professor Zhao Chengwen, an expert in appearance at China Criminal Police College, for help. I hope that through the way of portraits, I can show the appearance of children in their teens, and then look for people according to the portraits.

  A group of Sichuanese went to Guangdong again with portraits. There is no special way to extract the photos of school-age children and "look at them with the naked eye." This time, the task force brought back more than 300 suspected photos, informed parents to identify them, and finally determined more than 170 objects. But the DNA match, none of them match. Looking for someone failed again.

  "We will fight Wang Mouwen to the end, we can’t lose, but it is difficult to find a breakthrough." Jiang Xiaoling said that they almost exhausted the means of investigation. "I even went to the local area to find out which school-age children don’t look like their families, but it’s like looking for a needle in a haystack."

  In 2017, Sichuan police pushed the information of children to the local area through the help of Tencent QQ, and one child offered a reward of 30,000. At the same time, more than 10,000 circulars were printed and distributed in Shantou. "But the two jobs didn’t work. There were no valuable clues except receiving two calls asking whether the reward information was true or not."

  Looking for someone, deadlocked.

  On the one hand, there is a deadlock in finding people, and on the other hand, there are fast-growing children. Nearly 10 years after the incident, their appearance has changed dramatically. Traditional means have become more difficult. The turnaround occurred at the end of 2017. At that time, Chen Shiqu, deputy director of the Criminal Investigation Bureau of the Ministry of Public Security, went to Tencent for investigation. Li Xin, a security expert of Tencent Guardian Program, mentioned a new technology of cross-age face recognition. Subsequently, the technology was introduced to the Sichuan police, hoping to break through the case with scientific and technological strength.

  Caught in Trap

  Cross-age face recognition technology

  "Smart" and "mature" algorithms find 7 children.

  "At that time, Chen Bureau said that there was such technology and asked us if we would like to try it. We are definitely willing. " Jiang Xiaoling said. In 2018, Sichuan police officially cooperated with Tencent’s face recognition team — — Youtu laboratory docking.

  Cross-age face recognition is also a big problem in the world. It mainly learns the natural cross-age change law of face through algorithms and presents the cross-age change of face. The 10 children involved in the case are just in the growth period, with a large age span and great changes, and its difficulty is self-evident.

  "It’s very difficult, and I didn’t have a bottom before." On July 3 this year, Li Xin told reporters, "But if we can find these children through technology, it is also of great significance."

  Li Xin introduced that the face recognition team of Youtu Lab has done a lot of work for a long time to make the algorithm "smart" and "mature". In order to verify the accuracy of cross-age face recognition, team members also took their own photos for experiments at the annual meeting. What is exciting is that the end result is good.

  Sichuan police collected positive photos of all the children from parents and sent them to the technical team. In this regard, Jiang Xiaoling was impressed: "There are not many photos in the hands of parents. After their children are lost, these photos are even more entrusted with all their feelings and thoughts about their children, for fear of losing them."

  "After the Spring Festival in 2018, a number of results were produced. One person corresponds to 50 similar people, and the similarity scores are from high to low." Jiang Xiaoling introduced that the abduction police "digested" the data packet for several months, and then carried out ground investigation on the suspected objects with high similarity. In the end, at the beginning of 2019, the success ratio was 4.

  "I found it!" This is a result that excites everyone. At that time, Xiao-ling Jiang cried out excitedly, making it difficult to sit down in the office.

  Good news continued, and the second batch of 1 person and the third batch of 2 people were successfully found in the next two months. So far, seven abducted children have been found, and the similarity between the successful comparison and the recognition results is over 96.

  In May of this year, the CCTV program "Wait for Me" presented this technology to find people. Confirmed by Sichuan police and Tencent, this is the first time that cross-age face recognition technology has been used by the police to abduct and find people.

  However, there are also some puzzles. "Among the remaining three children who have not been found, there is a male doll. Every time the comparison is made, the first similarity is the same person. In any case, I think it should be this person, but the DNA can’t match." Jiang Xiaoling said, "We even went to check the birth situation of this child’s parents, but we still didn’t understand the reason."

  The kidnapper is a husband and wife.

  Looking for, still going on … …

  Looking for someone, still going on. With seven children found, Wang Mouwen, who has been sentenced to 15 years, will also face heavier punishment.

  The case-handling personnel restored Wang Mouwen’s personal experience to the reporter.

  In fact, Wang Mouwen’s first crime occurred in 2006. At that time, Wang Mouwen abducted a child in Hunan. In the process, the child cried and others called the police. Wang Mouwen was arrested and sentenced to 3 years in prison.

  "He was released from prison before the 2008 Olympic Games, and then he started committing crimes again." Jiang Xiaoling said that in 2008, 2009 and 2010, he committed 10 crimes, all in some counties or rural areas, taking the children away and then transporting them to Guangdong with his lover. "Accurately speaking, he is responsible for abducting children, and his wife is responsible for transporting them, because women with children are not easy to be suspected, which is ‘ Husband and wife file ’ Commit crimes. "

  Judging from the transaction records of Wang Mouwen’s bank found by the police, after Wang Mouwen brought his children to Guangdong to make a profit, he would deposit the money in the passbook, with the amount ranging from about 10,000 to about 100,000.

  "The amount that can be verified is at least more than 200,000." Jiang Xiaoling introduced.

  In 2010, after earning hundreds of thousands, Wang Mouwen took over and went to Qinghai to start a business. However, in just over three years, Wang Mouwen lost all his money.

  In 2014, Wang Mouwen decided to commit another crime. "on the one hand, the technique has been skilled and I feel that the money is fast; On the other hand, I feel that I have done it so many times before, and the police have not caught him. There is no way to take him. " Jiang Xiaoling said, but this time Wang Mouwen was quickly arrested by the police.

  At present, the police are doing further work and will increase the punishment for Wang Mouwen through judicial procedures.

  Chengdu Business Daily-Red Star Journalist Du Yuquan

  Intern Cheng Qiguo

Cell Stem Cell: dopaminergic progenitor cells derived from human embryonic stem cells in the treatment of Parkinson’s disease

Original biological world

Written by Cong Wang

Edit Wang Duoyu

Typesetting and writing in water

Cell therapy is considered to be very suitable for treating Parkinson’s disease (PD) because its pathogenesis is relatively simple and characterized by localized degeneration of dopaminergic neurons in the substantia nigra compacta of the midbrain. In animal experiments and human experiments, transplanting human fetal ventral midbrain tissue or cells has been proved to help restore motor function.

However, these results are often inconsistent, which highlights the need for improved cell therapy programs to ensure that a sufficient number of well-defined midbrain dopaminergic (mDA) neurons are produced and standardized cell preparation and transplantation procedures are adopted.

Recent technological progress has enabled human pluripotent stem cells (hPSC), such as embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), to efficiently generate mDA neurons, paving the way for establishing transplantation therapy for Parkinson’s disease based on hPSC. Many studies have shown that when transplanted into animal models of Parkinson’s disease, mDA progenitor cells derived from hPSC are well integrated into the host brain and mature into functional mDA neurons, which significantly improves motor function.

Recently, researchers from Yonsei University School of Medicine published a research paper entitled: preclinical and dose-ranging assessment of HESC-derived dopaminergic prognosticators for a clinical trial on Parkinson’s disease [1].

In this study, high-purity midbrain dopaminergic (mDA) progenitor cells were produced on a large scale from clinical human embryonic stem cells (hESC), and the safety and effectiveness of mDA progenitor cells were verified in vitro and in vivo. MDA progenitor cells improved the disease-related behavior of Parkinson’s disease rat model in a dose-dependent manner. Based on these preclinical research results, the research team obtained the approval of the Korean Ministry of Food and Drug Safety for the phase 1/2a clinical trial of cell therapy for Parkinson’s disease, and started the treatment of 12 patients with Parkinson’s disease.

In May, 2020, researchers at Massachusetts General Hospital reported a groundbreaking study in the New England Journal of Medicine (NEJM) [2]. A Parkinson’s patient who received autologous transplantation of mDA progenitor cells from hiPSC showed stable or improved clinical symptoms 24 months after implantation. Now, this method has been further developed, and the mDA progenitor cells derived from hiPSC and hESC began to enter the early clinical trial stage.

The first step in the clinical application of cell transplantation for Parkinson’s disease is to define the characteristics of cell products comprehensively. It is very important to determine whether cells are produced with clinical grade materials under GMP conditions and whether they meet the expected clinical use standards. Subsequently, preclinical research should produce convincing evidence of curative effect through large-scale animal experiments, and systematically examine long-term safety-related issues, such as toxicity, biological distribution and tumorigenicity. In addition, preclinical research needs to determine the optimal cell dose range for transplantation as a reference for human trials. Most importantly, the whole research design must be meticulous and the results must be evaluated in a fair way. This usually requires cooperation with CRO and extensive discussions with regulators.

This paper describes the process and results of a preclinical study aimed at using midbrain dopaminergic (mDA) neurons derived from human embryonic stem cells (hESC) in human clinical trials to treat Parkinson’s disease.

The cell differentiation method used in this study has been optimized for clinical application to ensure that it meets GMP standards. This optimization method can produce mDA progenitor cells with high purity and low temperature preservation on a large scale, while maintaining strict quality control. A year-long large-scale transplantation study by an independent CRO company using immunocompromised rats showed that the transplanted mDA neurons did not cause tumorigenicity, significant toxicity or ectopic integration outside the injection site. In addition, clinical mDA precursor cells showed therapeutic potential and dosage range, and produced therapeutic effects in toxin-induced semi-Parkinson’s rats. These findings provide the necessary information about the appropriate cell dose for human trials.

Specifically, this paper introduces the method of large-scale extraction of high-purity mDA progenitor cells from clinical grade hESC under strict GMP conditions, and also evaluates the toxicity, biological distribution and tumorigenicity of these cells in immunocompromised rats in facilities conforming to good laboratory practices (GLP). Different doses of mDA progenitor cells were transplanted into the semi-Parkinson’s rat model, and it was observed that there was a significant dose-dependent behavior improvement when the minimum effective dose ranged from 5000 to 10000 mDA progenitor cells. These results provide insights for determining the low cell dose (3.15 million cells) in human clinical trials.

Based on these experimental results, the research team obtained the phase 1/2a clinical trial of cell therapy for Parkinson’s disease approved by the Korean Ministry of Food and Drug Safety, and started the clinical trial of treating patients with Parkinson’s disease.

Paper link:

1. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00401-0

2. https://www.nejm.org/doi/10.1056/NEJMoa1915872

Read the original text

Don’t push the flu. Don’t delay these symptoms!

Influenza is called "influenza" in Chinese. Because of the word "cold" in it, many people think that it is a CommonCold, and they take it lightly, but in fact, getting the flu may cause serious consequences and even be life-threatening.

According to WHO estimates, influenza can cause 3 million to 5 million severe cases and 290,000 to 650,000 respiratory disease-related deaths worldwide every year. A global research data estimated the mortality of 33 countries from 1999 to 2015, and estimated the average annual influenza-related mortality as follows:

pneumonia

The most common complication of influenza

Clinically, people younger than 5 years old, older than or equal to 65 years old (there are also guidelines to limit them to more than 50 years old), pregnant women, people with chronic basic diseases within 2 weeks after delivery are listed as high-risk groups for complications. The risk of influenza complications in healthy young people is low, but the risk cannot be ignored.

Pneumonia is the most common complication of influenza, and its typical manifestations are cough with dyspnea, rapid breathing (> 24 beats/min), hypoxia and fever (> 3 days). Types of pneumonia include:

Primary influenza virus pneumonia: high fever persists 3 ~ 5 days after the onset of influenza, and there are the above pneumonia manifestations. It is usually very serious, and the progress may be rapid. Without active intervention, it will be life-threatening, especially for people with lung or cardiovascular diseases.

Secondary bacterial pneumonia: After the flu symptoms have improved (including fever), fever and expectoration occur again. It usually occurs a few days after the flu (7 ~ 14 days), and it is the most common, accounting for about 1/3 of severe flu. The secondary staphylococcus aureus pneumonia is often critical.

Bacterial and viral mixed infectious pneumonia: referring to the above two, it can be manifested as gradual aggravation of symptoms, or it can be manifested as aggravation after a short improvement.

These flu complications should also be noted.

In addition to pneumonia, influenza and these complications should also be careful:

Cardiac complications: myocardial ischemia, myocardial infarction and heart failure, accounting for about 12% of adult influenza, but influenza myocarditis and pericarditis are rare.

Complications of central nervous system: Seizures are more common in children and epileptic patients, and influenza-related encephalopathy is more common in children. Influenza causes adult encephalitis, cerebrovascular accident, acute disseminated encephalomyelitis and Guillain-Barre syndrome, which is not common in general.

Musculoskeletal complications: severe myositis and rhabdomyolysis (extreme myalgia, weakness and dark urine color) are more common in children. Although myalgia is a prominent feature of influenza, real myositis is not common.

Toxic shock: During the outbreak of influenza A and B in recent years, toxic shock-like syndrome appeared in previously healthy children and adults, mostly related to secondary infection.

Co-infection: including pneumonia (other viruses, bacteria and fungi), bacteremia, meningitis and aspergillosis. For influenza patients who have a fever for more than 3 ~ 5 days, have a fever again after the fever has gone down, or the symptoms continue to worsen after 3 ~ 5 days, they need to be vigilant.

What is the flu?

What’s the difference with the common cold?

Common cold symptoms

The typical common cold is usually characterized by runny nose and obvious nasal congestion. Other common symptoms include dry throat, itching or pain, cough and discomfort. Adult colds rarely have fever or low fever. Cough is more common, often appearing after symptoms of nasal congestion and runny nose; Nasal secretions may be thin or purulent (not necessarily bacterial infection).

flu symptoms

The biggest difference between flu and common cold lies in its severity. Different people have different symptoms after being infected with the flu. Mild symptoms are similar to colds, and severe ones will have the complications mentioned above.

Taking the flu lightly may lead high-risk groups to ignore vaccination or timely use of antiviral drugs, which may lead to serious and irreversible consequences. For example, due to neglect of vaccination, influenza causes serious comprehensive diseases, resulting in the death of children; For the elderly, this problem may be more hidden, but in clinic, we can often see that a seemingly ordinary cold may lead to a sharp decline in the physical condition of the elderly, or even inability to return to the sky.

It is sometimes not very accurate to distinguish flu from cold from symptoms. The quickest and most accurate method is pathogen detection. In clinic, if it is necessary to identify what kind of virus causes a cold, the methods can include virus culture, antigen detection and PCR. However, if there is no way to detect it in time, with the development of the disease, there may still be some differences in symptoms between the two:

Worldwide, influenza causes a large number of hospitalizations and deaths every year, which is a serious public health problem. Even for healthy adults, severe pain may occur after influenza infection, and the resulting temporary labor loss or quality of life decline is even more intense.

What should I do after I get the flu?

A self-judgment

For young people (15-65 years old) who are usually healthy, when they have flu cases in their own communities, schools, offices, etc., and suddenly have symptoms of fever, cough, myalgia or weakness, they can be clinically suspected of flu.

At this time, no flu test is needed to confirm the diagnosis. Home testing of self-purchased antigens is also an option, but due to the influence of sampling technology, the positive accuracy may not reach the expected 50% ~ 70%. When it is necessary to make a definite diagnosis, multiple sampling within 1 ~ 2 days will help to improve the positive accuracy.

With uncomplicated influenza, fever and respiratory symptoms of adults usually last for about 3 days, and then most of them will improve. It may take 10 ~ 14 days to fully recover (the recovery time is longer for the elderly and immunocompromised), and fatigue symptoms of some patients will last for several weeks.

Influenza with complications, or dehydration (thirst, fatigue, low urine yellow), impaired cardiopulmonary function, and mental state change are usually severe and should be hospitalized.

B When the flu is suspected or confirmed, it meets any of the following conditions and needs active antiviral treatment:

High-risk group of complications: antiviral treatment is recommended for influenza in high-risk groups, regardless of the severity of symptoms and whether the course of disease exceeds 2 days.

Contacts of high-risk groups: non-high-risk groups have influenza, but they will come into contact with high-risk groups (such as children and the elderly at home). No matter the severity of symptoms and whether the course of disease exceeds 2 days, antiviral treatment is also recommended.

Persistent or severe influenza: Influenza-like symptoms continue to progress for more than 3 days, or when influenza complications or severe influenza occur. It is recommended to follow the doctor’s advice and choose the corresponding antiviral drugs for timely treatment when the disease is severe or the course of disease exceeds 2 days.

C does not belong to the above three situations. Before taking medicine, weigh the pros and cons: the course of disease is within 48 hours, and you can decide whether to give antiviral treatment according to your own needs in life, work or study, because mild influenza can heal itself, and drugs can shorten the course of disease, but at the same time increase the risk of drug resistance.

If the course of the disease has been more than 48 hours and does not meet the above three requirements, antiviral treatment is not recommended.

Focus

Influenza can be very harmful, which can easily lead to serious complications, especially fatal to high-risk groups. Therefore, we must pay attention to influenza vaccination!

September and October are usually good times to get the flu vaccine every year, but even if you don’t get the vaccine before the end of October, you can get it throughout the flu season. Moreover, because the influenza virus is prone to mutation, the influenza epidemic strain may change every year, so the influenza vaccine should be vaccinated every year!

Ningbo eπ 008 price reduction is coming! The reserve price is 188,600, and the car is sufficient

[Autohome Ningbo Discount Promotion Channel] Recently, a fierce price reduction activity was launched in Ningbo area. At present, the maximum discount amount reaches 28,000 yuan, and the minimum starting price is only 188,600 yuan. If you are interested in this model, you may wish to hurry up and click the "Check Car Price" link in the quotation form to strive for higher discounts.

宁波eπ008降价来袭!底价18.86万,现车充足

eπ008采用了独特的前脸设计,其进气格栅采用了流线型的布局,与车身线条相融合,呈现出时尚动感的视觉效果。整体风格硬朗而精致,尽显现代科技气息。

eπ008车身尺寸为5002*1972*1732mm,轴距达到3025mm,前后轮距均为1650mm。车侧线条流畅,充满力量感,搭配265/45 R21的轮胎规格和动感的轮圈设计,展现出独特的运动风格。

宁波eπ008降价来袭!底价18.86万,现车充足

eπ008的内饰设计充满未来感,采用简洁大气的布局。方向盘为皮质材质,具备手动上下和前后调节功能,提供良好的驾驶体验。中控台配备一块15.6英寸的高清触控屏幕,支持多媒体系统、导航、电话以及空调的语音识别控制。车内共有前排2个USB接口和3个Type-C接口,满足不同乘客的充电需求,同时前排还配备了无线充电功能。座椅采用仿皮材质,主驾驶和副驾驶座椅支持前后、靠背、高低(2向)及腰部支撑(4向)调节,前排座椅还具备加热、通风功能,并为驾驶位配备头枕扬声器。此外,前排座椅具有电动记忆功能,方便驾驶员和乘客快速调整至最舒适的位置。第二排座椅同样支持前后调节、靠背调节和腿托调节,后排座椅可以进行比例放倒,为乘客提供更多灵活的空间使用方式。

宁波eπ008降价来袭!底价18.86万,现车充足

该车系配备了一台1.5T涡轮增压发动机,最大功率为108千瓦(147马力),在转速达到2000-3500转/分时可输出最大扭矩210牛·米。这款高效且紧凑的四缸发动机,搭配电动车单速变速箱,为车辆提供了强劲的动力输出和平顺的驾驶体验。

汽车之家车主在评价eπ008时提到,外观是他个人非常喜欢的感觉,“建议就买白色,大气还不用加钱。”这样的评价让我们看到,eπ008的外观设计确实能够打动许多消费者的心。

Qingdao Blue Electric E5 price reduction news, special offer 99,800! Limited time special offer

Welcome to the Autohome Qingdao preferential promotion channel, bringing consumers the latest and noteworthy preferential information. At present, the popular model we recommend to you – is giving back to consumers’ love with practical actions, and is carrying out a promotion with great intensity. In Qingdao area, car buyers can enjoy a cash discount of up to 40,100 yuan, making this model, which was originally priced between 99,800 and 140,900, now the minimum starting price has been reduced to an attractive 99,800 yuan. This discount range undoubtedly provides an excellent opportunity for friends who are interested in buying Blue Electric E5 to buy a car. To seize this rare discount opportunity, please click "Check Car Price" in the quotation form, let us explore more benefits and create your ideal driving experience together.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The exterior design of the blue electric car series E5 is very modern and technological. Its front face adopts a unique air intake grille layout with smooth lines, which not only enhances the visual impact of the vehicle, but also optimizes the aerodynamic performance. The overall style is exquisite and dynamic, integrating future design concepts, showing the persistent pursuit of detail and aesthetics of the blue electric E5.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The Blue Electric E5 presents a modern feel with its exquisite body design and smooth side lines. The body size is 4760mm x 1865mm x 1710mm, and the wheelbase reaches 2785mm, which makes the interior space layout of the vehicle more reasonable. The front and rear wheel tracks are 1585mm and 1580mm respectively, ensuring the stability and balance of the vehicle. The tire size is 225/55 R18. Whether it is the front or rear wheels, the same specifications are selected, and the elegant wheel rim style is combined to create the unique appearance aesthetic of the Blue Electric E5.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The interior design of the Blue Electric E5 is dominated by simplicity and technology, showing a refined and practical style. The steering wheel is made of leather material, which is delicate to the touch and supports manual up and down adjustment to adapt to the driver’s needs. The center console is equipped with a large 12.3-inch central control screen, which integrates multimedia systems, navigation, telephone, air conditioning and sunroof control, providing drivers with comprehensive information and convenient operation. The seat part is made of imitation leather material, which makes it comfortable to sit and wear-resistant. The main and passenger seats support front and rear adjustment, backrest adjustment and high and low adjustment to meet the individual needs of different drivers and passengers. The rear seats provide backrest adjustment function and support proportional reclining, which makes space utilization flexible. The overall interior design emphasizes both functionality and detail, creating a warm and efficient driving environment.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The car series Blue Electric E5 is equipped with a 1.5L displacement L4 engine, which has a maximum power of 81 kilowatts and a maximum torque of 135 Nm. It is matched with an advanced E-CVT continuously variable transmission, providing excellent performance and fuel efficiency for the vehicle.

Summarizing the evaluation of Autohome owners, the Blue Electric E5 won his admiration for its atmospheric and fashionable appearance and powerful lines, especially the domineering exposed air intake grille, which undoubtedly added a unique charm to this model. This is not only a bright spot in appearance, but also a manifestation of its inherent strength, making people look forward to the driving experience of the Blue Electric E5.

Double zero gravity seat + L2 smart driver, experience Trumpchi E8 Honor Edition

I believe many people know that the new energy car, the 200,000-level plug-in hybrid household MPV, can be oil and electricity, the main one is practical, but for consumers who do not have charging piles at home, it may not be so convenient. This, as a supplement, Trumpchi E8 has launched the Honor version model, which is equipped with GAC GMC260 super hybrid system, using 2.0ATK hybrid special engine, is a 2.0L engine and motor combination of oil and electricity mixing system, compared with the plug-in hybrid version less charging port, no need to charge, just add 92 gasoline, but due to the blessing of the motor, fuel consumption can also be done relatively low, and more friendly to users without charging piles.

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One sentence comment on Trumpchi E8 Honor Edition:

The starting threshold is further lowered, the space is spacious and flexible, the fuel consumption is not high, and it is equipped with a side sliding door. The 7-seat MPV with sufficient configuration and guaranteed comfort is coming.

Advantages:

1, 2 + 2 + 3 layout, flexible space

2. Fuel consumption has advantages over similar fuel MPVs

3. Just refuel, no need to charge, more friendly to users with inconvenient charging

4, equipped with L2 level intelligent driving assistance system and 540 ° high definition panoramic image, etc

5. The second-row zero-gravity seats are well received, and the comfort is guaranteed

Insufficient:

1. Compared with the plug-in version, the average energy consumption and other vehicle costs will be higher

2. You cannot get a green card. In some restricted cities, you need to consider the issue of license indicators

In terms of appearance, the Trumpchi E8 Honor Edition is basically not much different from the PHEV plug-in version, the main difference is reflected in the cancellation of the charging interface design on the side of the body. The front face still adopts the familiar large-size trapezoidal air intake grille, the segmented chrome-plated horizontal bar decoration is highly recognizable, and the two sides are slim-shaped split headlights. The body size of the car is 4920 × 1900 × 1760mm, and the wheelbase is 2930mm, which is the same as the size data of the plug-in hybrid version.

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In terms of interior and configuration, the Trumpchi E8 Honor Edition of this test drive comes standard with 8.88-inch digital LCD instrument + 14.6-inch high definition central touch display, Qualcomm Snapdragon 8155 chip, leather seat, main driver 6-way adjustment power seat, etc., as well as 540 ° high definition panoramic image, L2 level driving assistance, front seat ventilation and heating and other practical functions.

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The second row of double zero-gravity seats includes electric leg rests + electric backrests + electric cushions, while supporting lateral adjustment, allowing for a comfortable near-flat lying space in four-seat mode. The third row of seats is cleverly designed to hide or fold back, and fishing seats like that are retained and equipped with child safety seat interfaces.

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In terms of space, even when fully loaded with 7 people, the loading space is still excellent. Thanks to the sufficient depth of the trunk, the trunk of the 7-seat model E8 can also hold 2 24-inch suitcases + 5 20-inch suitcases or golf bags. When three rows are overturned, the trunk can hold 12 24-inch suitcases. If the second row of seats is slid to the front position, it can be increased to 15 24-inch suitcases. Even when the second row of seats is in the normal position, large and small non-folding bicycles can also be placed. In addition, there are 32 storage spaces + 13 hooks designed to meet various travel storage scenarios for families.

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In terms of power, as mentioned above, the new car is equipped with an i-GTEC 2.0 super hybrid system, which consists of a 2.0L naturally aspirated engine and a motor, of which the maximum power of the engine is 140 horsepower and the maximum torque is 180N · m; the maximum power of the motor is 182 horsepower and the maximum torque is 300N · m. It is matched with a second-speed DHT hybrid special gearbox. The WLTC comprehensive fuel consumption is 5.58L/100km. After actual experience, this power system is relatively smooth to drive, and the comfort is also guaranteed. It is really good for home use.

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The Trumpchi E8 Honor Edition can be said to be a two-child dad car that meets the family’s 7-seat travel needs, is comfortable to ride, and is easy to drive. It will be officially launched on July 16. If the price is right, it has the potential to become a hit. You can look forward to it.

Crown refreshed/four models, analyzing the new generation of Toyota Crown

  The ninth-generation Crown was launched in October 1991. This generation of models was divided into a four-door hardtop version and a higher-end MAJESTA series. The four-door sedan and four-door station wagon of the same period followed the chassis of the eighth-generation Crown, and the appearance was modeled after the ninth-generation Crown. The ninth-generation Crown was revamped in 1993 and the appearance was redesigned. A total of 284,000 cars of this generation of Crown were produced.

Autohome

  At the end of 1991, the Crown JZS133 (commonly known as: Crown 133), which was converted from the eighth-generation Crown four-door sedan, began to be sold in China. The domestically imported "Crown 133" adopts the Toyota logo on the front and rear, and there is a prominent Crown logo on the engine cover. The car is equipped with a 3.0-liter inline 6-cylinder engine, which is divided into Super Saloon models matching a 5-speed manual transmission and Royal Saloon models matching a 4-speed automatic transmission. This generation of models has a huge number of domestic sales.

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  The tenth-generation crown was launched in August 1995, and the models included a four-door hardtop and a four-door sedan, while the four-door travel version continued to be modified on the basis of the eighth-generation crown. In terms of appearance, the tenth-generation crown continued the previous generation’s rounded styling style, but it looked slightly tougher, and the overall atmosphere was still moderate.

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  In 1995, Toyota also launched the Crown Comfort model for the taxi market. The car has a shorter appearance length of only 4695mm, a width of 1695mm, a height of 1525mm, and a wheelbase of 2785mm. It is worth mentioning that the Crown Comfort in Japan has external rearview mirrors located on both sides of the fenders. In terms of power, the Crown Comfort is equipped with a 2.0-liter gasoline engine or a 2.0-liter LPG engine, which is matched with a 4-speed automatic transmission or a 5-speed manual transmission. In order to control costs and facilitate maintenance, the car adopts an integrated bridge non-independent rear suspension, and luxury equipment such as LCD dashboard and leather seats have been cancelled.

Autohome

  In the late 1990s, the 10th-generation Crown JZS155 (commonly known as: Crown 155) model imported into China continued to be equipped with a 3.0-liter inline 6-cylinder engine. The car was equipped with luxury configurations such as rear air conditioning system, rear seat electric adjustment, and rear multimedia control system. The 10th-generation Crown stopped importing in 2001, and the 11th-generation Crown after that was not available in China. Until 2005, the 12th-generation Crown began to be produced in FAW Toyota.

   The eleventh-generation Crown was launched in September 1999. The sedan version included the Royal series and the ATHLETE sports series. The station wagon version only had the ATHLETE sports series, and the four-door hardtop model was discontinued. However, this generation of models was only sold in the Japanese market and did not enter the Chinese market.

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A Brief History of Crowns (Part 2): The 12th generation of domestic crowns began in 2003

The 12th generation was officially put into production in China in 2005

  In December 2003, the 12th generation Crown was officially launched. This generation of models mainly provides four-door sedans, which are divided into: Royal series and ATHLETE sports series. At the same time, MAJESTA returned to the Crown series, while the 11th generation Crown station wagon continued to be sold. FAW Toyota’s domestic Crown was officially launched in March 2005, with a total of 7 models launched, with a price range of 32.8-48 million yuan. The domestic crown is based on the 12th-generation Crown Royal series. The main differences include: the domestic model initially provided only a 3.0-liter engine, and the direct injection technology was cancelled. Later, a 2.5-liter power version was added. The chassis of the domestic crown was raised by 10mm, and the four-wheel drive version was not provided. It also cancelled the active steering headlights and night vision system. The original engine cover was made of aluminum alloy, and the domestic version was changed to stainless steel.

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  Thanks to the good reputation accumulated by the "old crown" imported into China in the early stage, the crown once surpassed the Audi A6L in the early stage of domestic sales. The domestic crown ranked first in the medium and large car market with sales of 2,992 units in the first month of its listing. Two months later, the crown’s order exceeded 10,000 units. By the end of 2006, the crown’s sales volume exceeded 60,000 units, accounting for more than 30% of the premium car market. In 2007, the crown’s annual sales reached 53,104 units.

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  In February 2008, the 13th generation of the Crown model was released in Japan, initially launching the Royal, ATHLETE Sport, and MAJESTA models, followed by a Hybrid model. At that time, Toyota established the main competitor of the Crown in the Audi A6, BMW 5 Series, and Mercedes-Benz E-Class models.

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  More than a year after the 13th generation crown was released in the Japanese market, FAW Toyota officially made the 13th generation crown domestically. On December 14, 2009, the domestic crown based on the overseas version of the crown MAJESTA model was officially launched. The crown models listed at that time had a total of 2.5L, 3.0L and 4.3L three displacement 9 models, priced 326,800 yuan – 899,500 yuan. This generation of domestic models has been further upgraded compared with the overseas version of the MAJESTA. The main changes lie in the length and wheelbase. The domestic model is 75mm longer than the previous generation of domestic crown.

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  On December 25, 2012, the 14th generation crown was officially launched in Japan. This time, the crown released the Royal series and ATHLETE sports series, and also released a new hybrid version of the model. The MAJESTA version has not been launched yet. The shape design of the 14th generation crown has a relatively large change compared to the 13th generation. It adopts a new big-mouth front face design, a flatter and sharper light group shape, and LED daytime running lights are added to the lamp cavity. In addition, the lines of the C-pillar part are also more aggressive, and the lines at the bottom of the side are more layered.

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  This generation of domestic crown was first launched at the 2014 Guangzhou Auto Show. Like the previous generation, it is still based on the MAJESTA version of the overseas crown, and the wheelbase is 75mm higher than that of the overseas new generation of crown ordinary version. This generation of domestic models has 2.0T and 2.5L power options, and went on sale on March 12, 2015. At that time, the price range of the model was 27.98-38 5,800 yuan, which is enough for both the overall positioning and the entry price.

  In 2018, Toyota released the 15th generation model in the local market. The new car offers three power configurations and will be officially released on June 26. At the same time, the official price of the car in Japan was 460.62-718 7,400 yen, which is about 27-420,000 yuan. This generation of models is based on the GA-N rear drive platform under the TNGA architecture. The engine installation position under the new platform is reduced (the center of gravity is reduced by 15mm), and the sportiness is improved. However, this generation of models eventually failed to enter the Chinese market, and the previous generation (14th generation) was discontinued around 2018.

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Can Crown Lu Fang really continue the legend of the Crown series in China?

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  But the crown’s road in China is over? Of course not, although the 15th generation crown was not in the Chinese market, the crown as a "totem" later appeared in a place that we did not expect. At the Shanghai Auto Show in April 2021, FAW Toyota released the sister model of the GAC Toyota Highlander and named it the Crown Land Rover CROWN KLUGER. The car did not hang the Toyota bull’s head logo, but instead used the crown logo, which was outstanding.

editorial reviewWhat is it?

  After 67 years and a total of 16 iterations, a new crown family has appeared in front of us. From now on, Toyota Crown no longer just refers to the name of a car, but more comprehensive sub-products give it more partners and stronger strength. Based on the TNGA-K front-drive platform, it uses the same platform as Highlander and the new Camry in the future, and its comprehensive strength is evident. However, from the comments under the official picture news we released yesterday, everyone has mixed opinions on this appearance. As more content is revealed, will you change your opinion on it? As a global model, the new crown will be introduced to China as an imported car in 2022 and sold by FAW Toyota. However, I believe that with the launch of the new crown, more news will be announced one after another. Let’s wait and see.

  What else do you want to know about the new generation of crown? Or what do you think the price range and competitors are after it is introduced into China, etc. Welcome to the comment area to leave a message, and we will discuss the improvement together. See more exciting content, all in Autohome. (Text/Autohome Zhu Lishen, Zhong Weiqi, Liu Dong)