Why is the per capita usage time in Aauto Quicker still rising? Maybe it has something to do with the short play you are chasing and the Olympics.

Author | Before going to dinner

On August 25th, Aauto Quicker released Q2 financial report, with revenue of 19.138 billion yuan in the second quarter, up 48.8% year-on-year. After the continuous optimization of revenue structure, online marketing services accounted for 52.1%, live broadcast revenue accounted for 37.6%, other services (including e-commerce) revenue accounted for 10.3%, and the average daily usage time of daily users increased by 25.2% year-on-year.

Compared with these conventional data dimensions, we are more concerned about the new changes mentioned in the financial report.For example, the short play business was mentioned for the first time in the financial report. By the end of June this year, there were more than 800 series short plays in Aauto Quicker, and 40 of them were exclusive short plays hatched by Aauto Quicker Xingmang Project.

Of course, the short play is only a part of Aauto Quicker’s content. In recent one or two years, Aauto Quicker has been emphasizing the content strategy to improve user activity and participation. When the growth trend of UGC and PUGC is gradually stabilized, PGC will inevitably be put on the agenda.

On the PGC content side, in addition to the copyright of short plays and various Olympic events, Aauto Quicker has gradually made efforts to produce high-quality and serialized self-made content.On Entertainment Capital (ID: Yulezibenlun)It is learned exclusively that Aauto Quicker will launch a number of self-made variety shows intensively in the near future, covering pan-knowledge talk shows, love variety shows, food and entertainment, etc.

Aauto Quicker’s continuous expansion in content has been affirmed by Su Hua, CEO of Aauto Quicker.

He said in the second quarter earnings conference call that there are several reasons for the growth of Q2 earnings. First, the investment in technology has improved the user’s consumption experience. Secondly, a lot of content upgrades have been made, and short plays, sports, hot spots and other categories are outstanding; Thirdly, it also explores the videoization of user consumption scenes, for example, expanding the content supply of beauty, technology, finance, real estate and other categories, which realize the efficient link between people and services and bring new user value and commercial value.

The commercial value brought by content more reflects the linkage between content and e-commerce, and between content and brand marketing.

In Aauto Quicker, brands can find corresponding user groups here, ranging from dishes cleaning balls of a few cents to luxury goods and automobile categories of tens of thousands of yuan. During the June 16th this year, the Aauto Quicker E-commerce Shopping Festival also realized the whole process of the brand from planting grass and storing water in the early stage to accurately pulling weeds in the later stage.

It is worth noting that in the fourth quarter of 2020, the revenue generated by online marketing services in Aauto Quicker was 8.51 billion yuan, accounting for 47.0% of the total revenue, which exceeded the contribution of live broadcast business for the first time and became the most important source of income in Aauto Quicker. The proportion of Q2 online marketing revenue has reached 52.1%.

If content expansion was Aauto Quicker’s active choice, today, the data in Aauto Quicker’s financial report is just a natural result.

From Olympics to Short Play

Boutique content sets off Aauto Quicker’s summer growth target.

"I especially like to watch the drama filmed by Yu’ er, which is no worse than the TV series."

"Can you broadcast two episodes in two episodes? One episode is not enough."

This is the representative comment of Aauto Quicker users under the short play. In the summer of August, Aauto Quicker timely launched 50+ short dramas covering various scenes and categories, which set off the banner of consumption after the Olympic Games.

Objectively speaking, on the one hand, this action shows Aauto Quicker’s strength in developing and reserving large-scale projects, and on the other hand, it also shows the advantages of short plays’ flexibility and inclusiveness. After all, a long video platform can accommodate at most three plays competing on the same stage, while short plays mainly rely on "private domain+algorithm" for content distribution, so there is no situation that 50 plays compete for limited resources.

The increase in the scale of content will inevitably feed back consumption.According to official data, the number of people who watch short plays every day has exceeded 210 million, and the time they watch short plays exceeds 35 million hours every day, and users under 30 account for more than 50%.

Aauto Quicker solo short play.

Counting the performances of Aauto Quicker’s short plays in summer, an obvious conclusion is that Aauto Quicker’s short plays are qualified to compete with long plays in all aspects.

First of all, compared with the high cost and long production cycle of long dramas, the flexible and lightweight short drama production process is more efficient, and the plot development can be adjusted in real time according to audience feedback, ensuring that the most popular plot can be fully developed at the lowest cost.

Secondly, at the announcement level, more than 50 key works of the platform have reserved a large amount of work materials in the early stage. During the broadcast, the account corresponding to the plot will release tidbits and surrounding posters in line with the rhythm of the feature film. In addition, through the fan base of short dramas precipitated by official accounts, users’ stickiness to the drama and their trust in starring celebrities are further enhanced.

However, the IP parties in the upstream of the industrial chain have successively entered the market, which has accelerated the branding and IP development of short plays to some extent.

In October last year, Aauto Quicker and Mi Du reached an IP strategic cooperation. Recently, the officials of the two sides announced to further deepen cooperation and jointly create high-quality IP short plays. At present, there are 22 short plays adapted from the original novels of Mi Reading Platform, such as "Young Lady Becomes a Demon Again", "Flash Marriage and Lovely Wife", "Mad Princess of the Magical Doctor" and "Miss Song is Divorcing Every Day", among which many plays have exceeded 100 million.

The development trend of short drama content has brought higher user activity on the platform.

Take "Qin Ye’s Little Dumb" and "I am a group pet in the entertainment circle" as examples. The total broadcast volume of the two short plays reached 360 million and 320 million respectively, and even the broadcast volume of a single episode could exceed 100 million. Among them, the second day after the short play "Qin Ye’s Little Dumb" was launched, the number of new readers of the original works increased by 515.3%.

Just under the topic of "chasing the drama", 6,000 authors participated, and the number of topic views has exceeded 12.1 billion.

At present, Aauto Quicker’s short head plays are no less than long ones in terms of broadcast volume, topic degree and other data. Compared with the high cost and long production cycle of long dramas, the flexible and lightweight short drama production process is more efficient, and the plot development can be adjusted in real time according to audience feedback, ensuring that the most popular plot can be fully developed at the lowest cost.

"After the producer finalizes the IP, it only takes 4-6 weeks to get a miniseries online. The adaptation of the script takes the longest time, which may take three weeks; In the fourth week, choose the venue, choose the role, and prepare to serve the Tao; Take a week in the fifth week; In the sixth week, you can go online while editing. " A film and television production company revealed to Entertainment Capital.

According to this development rhythm and the logic of short play "distribution+private domain", the platform can deliver short videos that users like to watch to their hands at the first time.

Aauto Quicker’s content expanded to Zhang Zhilu.

In fact, since last year, Aauto Quicker has not been satisfied with promoting growth by sponsoring variety shows.Self-made content has been put on the agenda, and a content expansion movement centered on short plays, pan-knowledge, micro-variety and sports is being carried out in an orderly manner.

This year’s Spring Festival, supported by a strong live broadcast ecology, Aauto Quicker launched a 26-day live IP "Super Broadcast" on February 1st, bringing 300 stars and many Aauto Quicker talents to accompany users to welcome the Spring Festival.

It is not only close contact with stars and big coffees, but also a variety of program forms, covering parties, talk shows, speeches, secondary education and other fields, creating a more diverse and interesting exchange experience and effectively melting the generation gap of family topics. With the blessing of the stars, Aauto Quicker occupied a strong position in the Spring Festival scene, which subtly consolidated the audience’s cognition of Super Broadcast IP.

"The operation activities of Q1 Spring Festival have achieved quite good results, which helped us gain a large number of users and pushed up the user base of Q1." Aauto Quicker co-founder Cheng Yixiao analyzed.

In addition to the live broadcast upgrade, Aauto Quicker also expanded the self-made programs of sports, variety and other categories.After winning the copyright of the Tokyo Olympic Games in a big way, the platform launched Good Morning Lao Tie, the first year of the Olympic Games, Here comes the champion and Oh! The programs and activities, such as Champion, Aauto Quicker No.1 Scholar Olympic Answer Season, and Boasting Olympics, cover athletes’ daily training, news and information, entertainment variety, event explanation, player interaction and so on, forming a powerful Olympic content matrix.

According to the insiders, it is not difficult to find out from Aauto Quicker’s attempts in sports copyright that while investing in introducing copyright to increase the supply of content, more emphasis is placed on the possibility of "second creation" for platform users and creators.

In fact, this is not difficult to understand: on the one hand, having the right of secondary creation will further stimulate the creative desire of platform users and accumulate more content creators; On the other hand, users’ willingness to stay in the platform will naturally be stronger, which will lead to the improvement of usage time and stickiness.

It is also the top priority of the platform to rush to the pan-knowledge field.On June 24th, Aauto Quicker announced the launch of "New Knowledge Broadcasting in Aauto Quicker", which will link 100 knowledge café s, more than 100 professional organizations and over 1,000 Aauto Quicker knowledge anchors, bringing tens of thousands of live knowledge broadcasts in three months. Bring high-quality pan-knowledge content to users in a richer three-dimensional live broadcast form, and help knowledge creators realize realization on the platform, and build a closed loop of production and consumption of pan-knowledge content.

As Cheng Yixiao mentioned in the conference call yesterday, the user groups in Aauto Quicker are mostly young people, and their active data are greatly influenced by holidays. Therefore, the first and third quarters are often the DAU peak of the platform because of winter vacation and summer vacation.

In the third quarter, the year-on-year and quarter-on-quarter growth rate of DAU in Aauto Quicker continued to increase with the help of the Olympic Games and short drama summer stalls."So, we still have strong confidence in our annual growth target and the medium-term target of 400 million DAU." Cheng Yixiao said.

Brand power brought by content upgrading

From UGC to PUGC to PGC, behind the evolution of Aauto Quicker’s content ecology is the change of business format.

Aauto Quicker Q2 financial report shows that online marketing services grew strongly, with revenue increasing by 156.2% year-on-year to RMB 10 billion, accounting for 52.1% of the total revenue, which contributed more than half of the total revenue for two consecutive quarters. Among them, the income from brand advertising has maintained rapid growth, and the number of brand advertisers has increased nearly four times compared with the same period of last year.

At the same time, a major change in Aauto Quicker is that while doing effect advertising, it has begun to vigorously develop brand advertising, which will also cover more advertisers. Aauto Quicker’s online marketing business is more concerned about whether it can improve the efficiency of advertising realization.

Under this change, sports, short plays, science and technology, mother and baby, cultural tourism, food, etc. are continuously expanded horizontally in Aauto Quicker’s content market, and the content ecology is cultivated first, and then the industrial ecology is deeply cultivated and realized.

Take short plays as an example. Obviously, it can be seen in the market that the main force of content consumption groups has shifted from the post-70s and 80s to the post-90s and 00s, and users’ audio-visual content consumption preferences have gradually become fragmented and mobile, and more flexible and free short video drama-chasing mode and younger and more lively short drama content have gradually become the mainstream.

For consumers, good content is what attracts them most. Correspondingly, they want to communicate with users in a new track in an innovative way. Good content+suitable marketing scene+good brand display mode is the most concerned by the brand.

"The heat of the market can be clearly felt from the daily operation and commercialization. The most intuitive performance is that more and more customers are willing to try short plays. " Lu Jingjing, head of Aauto Quicker Magnetic Engine Entertainment Marketing Group, said.

At present, in addition to fast disappearing, the brands contacted by Lu Jingjing have been extended to first-line luxury cosmetics, famous cars, etc. The compatibility of brands and the reach of young users cannot be underestimated. Correspondingly, in terms of the demand for cooperative themes, the urban emotional category, which stood out from the past, is now developing in a hundred schools of thought: ancient styles, families, brothers and comrades-in-arms and other diverse themes have customer needs and user markets, and young people are breaking the circle in new forms.

"We will explore the videoization of more user consumption scenarios. For example, the content supply of beauty, technology, finance, real estate and other categories has been expanded. These categories have achieved efficient and long-term links between people and services, bringing new user value and commercial value. " On the earnings conference call, Aauto Quicker CEO Su Hua said.

According to the official data of Aauto Quicker, compared with 2019, in 2020, the number of people with income will increase by three times, and 80% of the vertical categories will be realized commercially. Among them, there are 5 vertical categories with income exceeding 100 million and 20 KOL vertical categories with income exceeding 10 million.

Where the traffic is, the marketing is there. The brand’s playing style in Aauto Quicker is more and more diversified, and the marketing link is greatly shortened.

This year, at the "Aauto Quicker 616 Sincere Night" event organized by Aauto Quicker E-commerce, Jiangsu Satellite TV and Zhejiang Satellite TV, Hua Xizi, as the general title, also took the form of fancy implantation and linkage communication, and the marketing effect was full.

The data shows that the first network-linked party initiated by the live broadcast e-commerce industry attracted a total of 236 million people to watch, setting a total of 43.1 billion network exposures and 300+ network hot searches, which not only comprehensively enhanced the brand influence of Huaxi Zi, but also directly helped the GMV of Huaxi Zi’s live broadcast room in Aauto Quicker to grow by more than 13 times.

Before 2019, Aauto Quicker belonged to a relatively pure content community and social platform. The platform mainly focused on both content creators and content consumers, with little business ecology. From the second half of 2019, Aauto Quicker began to introduce high-quality content creators through a series of plans to improve the content ecology.

Driven by the content, Aauto Quicker’s business model has also stepped out of the era of live reward and entered the stage of multi-head.

In fact, when the product was upgraded last year, a "two-story" theory was put forward in Aauto Quicker, that is, content and industry are connected but separated. If the extension of short video and live broadcast is too short, the content can be connected to the industry, and through the access of the industry, more creators can be driven to join the content matrix of the platform, thus becoming a growing self-circulation system.

It can be seen from this theory that Aauto Quicker’s answer is a longer-term and broader answer to the long-term growth of the platform, which is also the reason for his subsequent progress in pan-life services, short plays and sports.

For Aauto Quicker at this stage, as long as the content ecology continues to prosper and the community is active enough, its commercial exploration space is large enough.

Topic interaction:

Which short play do you like best? Come and talk to us in the comments section ~

Express: Everyone here may be short of folic acid.

Original DY MedSci Metz

Lead: spoiler of folic acid new consensus.

Medical news today

On September 5th, the conference of "Consensus of Multidisciplinary Experts on Reasonable Clinical Folic Acid Supplement in China" was successfully held in Beijing. After being checked by authoritative experts, the consensus gives personalized and detailed folic acid supplementation suggestions to the general population and the special population according to different physiological stages.

Folic acid is a water-soluble B vitamin, which naturally exists in some foods, can also be added to other foods, and can be used as a dietary supplement. "Folic acid" used to be called "folic acid protein", sometimes also called "vitamin B9", which is a general term for naturally occurring food folic acid and folic acid in dietary supplements and fortified foods. Food folic acid is in the form of tetrahydrofolic acid (THF), which usually has other glutamic acid residues, making it a polyglutamate. Some dietary supplements also contain 5-methyl -THF (also known as L-5-MTHF, 5-MTHF, L- methyl folic acid or methyl folic acid) in the form of monosodium glutamate.

Folate, wiki

Folic acid helps to form DNA and RNA, and participates in protein metabolism. It plays a key role in the decomposition of homocysteine, which is an amino acid. If the content is too high, it will have harmful effects on human body. Folic acid is also needed to produce healthy red blood cells. Folic acid is very important in the period of rapid human growth, such as pregnancy and fetal development. Therefore, folic acid deficiency is closely related to the occurrence and development of many diseases, such as neonatal neural tube defects (NTDs), various pregnancy damages (abortion, premature delivery, etc.), hypertension, stroke, abnormal mental behavior and other cognitive disorders.

Who is short of folic acid?

The following situations may increase people’s risk of folic acid deficiency:

1. drinking too much. Alcohol will interfere with the absorption of folic acid and accelerate the decomposition of folic acid. In addition, alcoholics tend to eat inferior diets with low folic acid content, which increases the risk of folic acid deficiency in this group of people.

2. Pregnancy. Because folic acid plays an important role in fetal cell development, the demand for folic acid will increase during pregnancy.

3. Intestinal surgery or digestive system diseases. Surgery involving digestive organs or lowering normal gastric acid levels may affect folic acid absorption. Celiac disease and inflammatory bowel disease can also reduce the absorption of folic acid. Studies show that about 20%-60% of patients with inflammatory bowel disease suffer from folic acid deficiency.

4. Genetic variation. People with MTHFR gene mutation can not convert folic acid into its active form, which accounts for about 29% of Hispanic population, 10% of Caucasians and Asians, and 1% of African-Americans.

Lack of folic acid may lead to anemia, weakness and fatigue; Irregular heartbeat; Shortness of breath; It is difficult to concentrate; Hair loss; Pale skin; Symptoms such as aphtha.

How do the general population supplement folic acid?

In fact, folic acid deficiency is rare, but some people may be in marginal folic acid state. Folic acid can’t be synthesized in the human body and can only be taken from food. For individuals with folic acid deficiency or deficiency, it is first recommended to supplement folic acid with "food therapy" by improving diet structure. The consensus points out that green leafy vegetables, bean products, animal livers, lean meat and egg yolks are good food sources of folic acid, and chicken livers (1172.2μgDFE/100g), amaranth (419.8μgDFE/100g), pig livers, sheep livers and soybeans are rich in folic acid. Foods with folic acid content ≥ 120 gdfe/100g (solid) or 60μgDFE/100g (liquid) are "high or rich in folic acid", and foods with folic acid content or folic acid source are half. However, if the absorption and utilization rate of natural food is low, the general population should also take measures such as folic acid supplement or fortified food, and the effective and safe dose is 0.4-1mg per day.

Photographing network

However, it should be noted that long-term large-dose (> 1 mg) folic acid supplementation may cause health risks. Studies have shown that taking more folic acid can mask vitamin B12 deficiency. This deficiency most often occurs in the elderly or people who eat vegetarian food, among which B12 deficiency is more common. Folic acid and B12 are both involved in the production of red blood cells, and the shortage of either will lead to anemia. People who take high-dose folic acid supplements may correct anemia and feel better, but B12 deficiency still exists. In this case, if high folic acid intake continues to "mask" the symptoms of B12 deficiency for a long time, it may cause slow but irreversible damage to the brain and nervous system. In addition, long-term folic acid overdose also has the effects of increasing cancer risk, aggravating neurodegenerative diseases, affecting zinc absorption and reducing immunity. Therefore, it is suggested that if natural folic acid is still available every day, folic acid supplements should not be used more than 400μg per day.

How do special people supplement folic acid?

Pregnant women (including pregnant women)

During pregnancy, folic acid demand will increase due to nucleic acid synthesis. Folic acid deficiency during perinatal period will increase the risk of NTDs, leading to birth defects of fetal spine (spina bifida) and brain (anencephaly). Fifty years ago, no one knew what caused these birth defects. Later, two large trials randomly assigned women to take folic acid or placebo, showing that too little folic acid would increase the birth probability of deformed babies, and getting enough folic acid could greatly reduce this incidence.

In addition, folic acid deficiency during pregnancy may also increase the risk of abortion, premature delivery, stillbirth, megaloblastic anemia, pregnancy-induced hypertension, autism spectrum disorder’s offspring and other diseases.

At present, folic acid supplementation for women of childbearing age is a basic policy in China. The incidence of NTDs in China decreased from 27.4/ 10,000 in 1987 to 1.5/ 10,000 in 2017, a decrease of 94.5%.

The blood folic acid level of rural women in northern China is low. The research results show that this group of people can reach the level of preventing NTDs by taking folic acid 0.4mg/d for at least three months. In addition, many studies suggest that increasing dietary folic acid intake can also reduce the risk of NTDs by about 30%-60%.

Therefore, it is suggested by consensus that women should try their best to take food supplements during pregnancy preparation and early pregnancy, and women in the middle and late pregnancy and lactation can take food supplements and folic acid supplements. It is suggested to supplement folic acid 0.4mg/d or 0.8mg/d from the possible pregnancy or at least 3 months before pregnancy until the third month of pregnancy. The intake of folic acid in the second and third trimester of pregnancy should reach 600 gdfe/d, and it is suggested to supplement folic acid with 400 gdfe/d in addition to food supplement. It is recommended to take 550 gdfe/d folic acid during lactation, and it is recommended to supplement 350 gdfe/d folic acid in addition to food supplement. Personalized supplements are needed for people who live in the north, eat less vegetables and fruits, and have low blood folic acid levels. For women with NTDs reproductive history, diseases such as diabetes, and TT genotype at MTHFR677 locus, the consensus also made tailor-made suggestions.

Cardiovascular disease

The increase of Hcy level caused by folic acid deficiency is considered as an independent risk factor for atherosclerosis and cardiovascular and cerebrovascular diseases. Folic acid deficiency Several large-scale randomized trials of B vitamin supplements to reduce homocysteine levels and prevent heart disease and stroke have not found the benefits of folic acid supplementation. These trials have a similar design: adults with a history of heart disease or stroke or at high risk of heart disease are given pills or placebos containing high doses of vitamins B6, B12 and folic acid. Studies have found that taking high doses of three B vitamins can reduce the level of homocysteine, but it does not lead to a decrease in coronary heart disease events.

However, looking at cardiovascular diseases as a whole may mask the potential benefits of at least one B vitamin, and it may be too late to study people with advanced vascular diseases. An analysis of several studies shows that folic acid supplements can reduce the risk of stroke in people who have not yet had a stroke, but they cannot reduce the risk of a second stroke in people who have already had a stroke.

Effect of folic acid supplementation on stroke risk in preset subgroups

Therefore, it is not recommended to use folic acid to prevent cardiovascular diseases, but folic acid supplementation is recommended for cardiovascular high-risk groups and hypertensive patients with HHcy to reduce Hcy levels. In order to reduce the risk of the first stroke, folic acid monotherapy or fixed compound preparation containing folic acid can be used for patients with HHcy with hypertension. Taking 0.8mg folic acid combined with vitamin B12 daily can achieve the best effect of reducing Hcy.

Neurobehavioral disorders

1. autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which is characterized by difficulties in communication and interaction with others, limited interests and repetitive behaviors. More and more evidence shows that folic acid supplementation during pregnancy may reduce the risk of ASD or reduce the increase of ASD risk caused by prenatal exposure to certain drugs and toxic chemicals. The mechanism of these potential benefits is not clear, but it may be related to the role of folic acid in DNA methylation, which in turn will affect neural development.

Some (but not all) observational studies show that there is a correlation between the use of folic acid and/or multivitamin supplements by pregnant women before and/or during pregnancy and the lower risk of ASD in female offspring. A case-control cohort study of 45,300 Israeli children in 2018 showed that the risk of ASD in children was significantly reduced when mothers took folic acid and/or multivitamin supplements before and/or during pregnancy.

Up to now, the evidence shows that there may be a negative correlation between folic acid intake of mothers during pregnancy and the risk of ASD in their offspring, but there is no evidence to support it in large-scale clinical studies. In addition, some studies believe that children with ASD also have different degrees of abnormal folic acid metabolism due to bad eating behavior, so not exceeding folic acid in these children may be beneficial to the treatment of ASD, but there is still a lack of clinical evidence. Therefore, it is recommended that women of childbearing age should be supplemented with 0.8mg/d regularly to reduce the risk of ASD in their offspring.

2. Depression

Nowadays, depressive disorder has become the second disease in China, with a prevalence rate of 3.02%, ranking first in the total burden of various mental diseases. Some studies have shown that folic acid deficiency is related to depression and low response to antidepressants. The mechanism may be related to the involvement of folic acid in the synthesis of neurotransmitters in the brain. In addition, HHcy is related to depression, and folic acid can degrade Hcy.

In a racial diversity study of 2948 Americans aged 15-39, the concentration of folic acid in serum and red blood cells of patients with severe depression was significantly lower than that of patients who had never suffered from depression. Some clinical studies have shown positive results about whether folic acid supplementation may help depression when used with traditional antidepressants. In addition, the guidelines for the treatment of depression revised by the British Psychopharmacology Association in 2015 and the Canadian network for the treatment of depression and anxiety both recommended folic acid as a supplement to the treatment of serotonin reuptake inhibitors for depression. Therefore, the consensus is that folic acid deficiency is related to depression, and low folic acid level is related to low response of antidepressants. It is recommended that patients with depression should be supplemented with folic acid reasonably on the basis of antidepressants, especially serotonin reuptake inhibitors, and the recommended dose is 0.5-2.5 mg/d.

Cognitive dysfunction

Statistics show that there are 178 million elderly people over 60 years old in China, accounting for about 13% of the total population. There are about 50 million people with dementia and cognitive impairment, and the social burden is huge. Most observational studies conducted so far show that there is a positive correlation between HHcy and the incidence of dementia. Scientists hypothesize that the increase of homocysteine level may have negative effects on the brain through various mechanisms, including the death of neurons caused by cerebrovascular ischemia, abnormal deposition of tau kinase activation and inhibition of methylation reaction.

A Dutch study involving 818 subjects aged 50-70 years showed that folic acid supplementation could reduce Hcy concentration by 26%. Although the cognitive function of subjects declined with age, the folic acid group was superior to the placebo group in memory, information processing speed and sensory motor speed.

Although folic acid supplementation can effectively reduce the level of Hcy, and hypercholesterolemia is an independent risk factor for dementia, based on the current evidence-based medical evidence, it cannot be considered that folic acid supplementation can significantly improve cognitive function. Therefore, the consensus points out that people with cognitive impairment should not advocate long-term use of folic acid without evidence of folic acid deficiency. For those with folic acid deficiency, folic acid 0.8 mg/d can be supplemented (grade C evidence).

kidney disease

Chronic kidney disease (CKD) can lead to Hcy excretion disorder, and dietary restriction in such patients can also increase the risk of folic acid deficiency. Can folic acid supplementation delay the progress of CKD? China’s CSPPT study pointed out that compared with simple antihypertensive therapy, folic acid supplementation of 0.8mg/d can reduce the progress of CKD. But foreign studies show negative results. It is speculated that the difference of research conclusions may be related to the different baseline folic acid levels, that is to say, fortified foods have not been used to supplement folic acid in China, so folic acid supplementation may be beneficial to delay the progression of nephropathy for people with low baseline folic acid levels.

The consensus suggests that folic acid should not be routinely used to delay the progress of CKD, but folic acid supplementation (0.8mg/d) should be considered for patients with folic acid deficiency.

In addition, in the field of cancer, some epidemiological studies show that folic acid intake (or status) is inversely related to colorectal cancer and lung cancer. The exact nature of folic acid on carcinogenesis has not been established, but scientists speculate that folic acid may affect cancer development through its role in carbon metabolism, DNA replication and cell division. Evidence also shows that folic acid may play a dual role in the occurrence and development of cancer. That is to say, folic acid may inhibit some types of cancer in the early stage of development, and taking large doses of folic acid after the establishment of precancerous lesions may promote the development and progress of cancer. We need more research to fully understand how folic acid in diet and folic acid supplementation affect cancer risk, and whether their effects vary with exposure time.

In a word, folic acid is firmly listed in the World Health Organization standard list of essential drugs, and it is one of the most effective and safe drugs needed in the basic public health system. The application of folic acid has achieved great success in improving neonatal malformation, and its application prospect in other fields and disciplines is also very promising. With the deepening of future research, scientists will also find and solve more problems and set more precise guidance for personalized folic acid use.

Note: The content of this article is only for promoting consensus and popular science, and it is not intended to provide personal medical advice.

references

1.Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation.DOI: 10.1056/NEJM199212243272602.

2.Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study.DOI:https://doi.org/10.1016/0140-6736(91)90133-A.

3.Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B12 vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors.doi:10.1001/jama.2010.840.

4.B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial.DOI:https://doi.org/10.1016/S1474-4422(10)70187-3.

5.Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention.https://doi.org/10.1161/STROKEAHA.109.573410.

6.Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring.JAMA Psychiatry. 2018; 75(2):176-184. doi:10.1001/jamapsychiatry.2017.4050.

7.Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.DOI:https://doi.org/10.1016/S0140-6736(07)60109-3.

8. Information on the conference of China Multidisciplinary Expert Consensus on Reasonable Clinical Folic Acid Supplement.

Source: Metz Medical Comprehensive Report

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Play and eat! Wenzhou people’s nightlife is wonderful!

Xiaobu learned from the Municipal Housing and Construction Bureau that according to the previously issued Notice on the Selection of Moonlight Economic Agglomeration Areas and Demonstration Sites in Wenzhou City, the city started the selection work in March this year.

After independent declaration by enterprises, review by local departments, expert review and publicity by municipal departments, Longwan wanda plaza, Park Road Historical and Cultural Block, Zhonggeng Wandering World, Impression Nantang Style Pedestrian Street and Dongtou Leek ‘ao Beach Park were finally selected as the Moonlight Economic Cluster and Demonstration Sites in Wenzhou City.

Longwan wanda plaza

Since 2020, Longwan wanda plaza has started to promote the development of moonlight economy projects. After three years of planning, night economic development has begun to take shape, including trunk market, fashion leisure square, parent-child play, late-night food, music festival and so on. Later, modules such as music corridor, national tide street and tide shopping will be developed one after another.

Up to now, wanda plaza has held fireworks fairs with different themes for four years in a row, such as Wanshi Daji, Different YOUNG Market and Antique Market, and invited Wenzhou local bands to hold more than 200 night economic activities such as camping music festivals in the outer square, with an average daily passenger flow of over 50,000 and a holiday passenger flow of over 100,000.

In the next step, Longwan wanda plaza will focus on the introduction of night consumption IP development and the opening of market projects, continue to carry out night cultural theme activities, and strive to promote the pilot construction of moonlight economy industry in wanda plaza.

Gongyuan road historical and cultural block

Park Road historical and cultural block takes culture as the breakthrough point, and on the basis of retaining the traditional Wenzhou living format of Park Road, it adds non-genetic inheritance, cultural experience, street life, traditional food, homestay inn, leisure and entertainment, supporting business and fashionable catering to complement the original format, and strives to make the block a benchmark for urban core cultural and business travel.

In recent years, fun cultural activities, such as blocking the street, Hanfu, national tide flash parade, folk taste experience activities, immersive clothing street show, Zanhua market, spring market, "summer fun nightlife" market, antique market, sports night and so on, have been constantly presented, and many good plays with strong regional characteristics, such as Yue opera, Wenzhou drum performance, Ou Yue landscape poetry recitation, have been staged on the ancient stage in turn.

The street block closely combines Wenzhou’s Song Yunou style with the aesthetics of fireworks life, and new formats are constantly emerging, which endows the night market with popularity through the traffic attributes of the street block and drives the new growth of night consumption.

Zhong Geng you man Tian di

Zhong Geng Roaming World is located in the core of ouhai district CBD. By creating characteristic night scenes, combining with rich and wonderful performances and constantly changing the stalls and forms of categories, the new "play" of moonlight economy is realized.

As the largest wai-wai square in Wenzhou’s main city, relying on the square public space of over 20,000 square meters, Zhonggeng Roaming World has built three central squares, namely Lohas Square, Chaotong Square and Creation Square, which span and connect six office corridors. Combined with business planning and scene creation, it has gathered the characteristic food, entertainment, fashion, literary play and creation market, forming a "flagship" of fashionable and personalized social interaction.

In the next step, the block will cooperate with the cultural tourism department to create a "literary spark to beautify" project, which will be presented with the theme of Four Seasons Music Box. As a commercial supporting project of the Dragon Boat Base, the venue of the Dragon Boat Race in the Asian Games, dragon boat elements are added to the original night market activities, which helps the Asian Games and adds a unique cultural innovation vitality to the block night market.

Impression nantang style pedestrian street

In recent years, Impression Nantang Scenic Area has become the "golden business card" of Wenzhou night tourism, creating a business pattern of night scene+night shopping+night entertainment+night leisure, with distinctive economic characteristics at night, which has formed agglomeration effect and brand effect.

"Tanghe Night Painting" is an important part of the "Moonlight Economy" in Nantang Scenic Area. It highlights the local cultural heritage of Wenzhou in the form of light and shadow technology and real-life interpretation, and shows the urban temperament of "poetry and painting landscapes, a warm state". The "Nantang Night Shop" in the block is another feature of the pedestrian street. Apart from the fashionable, literary and retro street, there are also online celebrity cuisine and various local snacks to satisfy the taste buds of tourists.

Since the block was fully opened, the average annual passenger flow has reached 5 million, and the annual rent and self-operated income can reach more than 50 million yuan. In the next step, with the advantage of Wenzhou cultural industry, the block will improve supporting industries such as creative planning, venue management and exhibition design, and create a special festival cultural exhibition block.

Dongtou Jiucaiao Beach Park

In recent years, Wenzhou Dongtoumuxinhe Cultural Tourism Development Co., Ltd. has broken through the original beach entertainment mode and introduced 10 new marine sports products, such as rainbow parasailing, sailing, sea motorboat and trapeze performance, which has made its popularity "prosperous".

Chive ‘ao Beach focuses on creating a special seafood snack block, Dongtou intangible cultural heritage workshop, music night market, local folk performing arts, sea garden fireworks festival, sea drone light show, bonfire party, fishing port night tour, island star watching, camping and other projects, realizing the full connection of "day viewing+night consumption" and enriching the collection of "night tour, night rest, night banquet, night appreciation, night tour.

In order to solve the dilemma of inconvenient transportation on the island and enrich the highlights of coastal leisure and holiday tourism, the recently built Leek Ao Blue Bay Resort Center opened in July to welcome guests, which perfectly matched the night economy of Leek Ao Beach and injected new vitality into the scenic spot. In the next step, we will continue to explore the local culture of Dongtou and the island characteristics of moonlight economy, so that the traffic will become "reserved" and continue to light up the moonlight economy.

Original title: "Play and eat! Wenzhou people’s nightlife is wonderful! 》

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