标签： 上海后花园龙凤

Express： Everyone here may be short of folic acid.

Original DY MedSci Metz

Lead: spoiler of folic acid new consensus.

Medical news today

On September 5th, the conference of "Consensus of Multidisciplinary Experts on Reasonable Clinical Folic Acid Supplement in China" was successfully held in Beijing. After being checked by authoritative experts, the consensus gives personalized and detailed folic acid supplementation suggestions to the general population and the special population according to different physiological stages.

Folic acid is a water-soluble B vitamin, which naturally exists in some foods, can also be added to other foods, and can be used as a dietary supplement. "Folic acid" used to be called "folic acid protein", sometimes also called "vitamin B9", which is a general term for naturally occurring food folic acid and folic acid in dietary supplements and fortified foods. Food folic acid is in the form of tetrahydrofolic acid (THF), which usually has other glutamic acid residues, making it a polyglutamate. Some dietary supplements also contain 5-methyl -THF (also known as L-5-MTHF, 5-MTHF, L- methyl folic acid or methyl folic acid) in the form of monosodium glutamate.

Folate, wiki

Folic acid helps to form DNA and RNA, and participates in protein metabolism. It plays a key role in the decomposition of homocysteine, which is an amino acid. If the content is too high, it will have harmful effects on human body. Folic acid is also needed to produce healthy red blood cells. Folic acid is very important in the period of rapid human growth, such as pregnancy and fetal development. Therefore, folic acid deficiency is closely related to the occurrence and development of many diseases, such as neonatal neural tube defects (NTDs), various pregnancy damages (abortion, premature delivery, etc.), hypertension, stroke, abnormal mental behavior and other cognitive disorders.

Who is short of folic acid?

The following situations may increase people’s risk of folic acid deficiency:

1. drinking too much. Alcohol will interfere with the absorption of folic acid and accelerate the decomposition of folic acid. In addition, alcoholics tend to eat inferior diets with low folic acid content, which increases the risk of folic acid deficiency in this group of people.

2. Pregnancy. Because folic acid plays an important role in fetal cell development, the demand for folic acid will increase during pregnancy.

3. Intestinal surgery or digestive system diseases. Surgery involving digestive organs or lowering normal gastric acid levels may affect folic acid absorption. Celiac disease and inflammatory bowel disease can also reduce the absorption of folic acid. Studies show that about 20%-60% of patients with inflammatory bowel disease suffer from folic acid deficiency.

4. Genetic variation. People with MTHFR gene mutation can not convert folic acid into its active form, which accounts for about 29% of Hispanic population, 10% of Caucasians and Asians, and 1% of African-Americans.

Lack of folic acid may lead to anemia, weakness and fatigue; Irregular heartbeat; Shortness of breath; It is difficult to concentrate; Hair loss; Pale skin; Symptoms such as aphtha.

How do the general population supplement folic acid?

In fact, folic acid deficiency is rare, but some people may be in marginal folic acid state. Folic acid can’t be synthesized in the human body and can only be taken from food. For individuals with folic acid deficiency or deficiency, it is first recommended to supplement folic acid with "food therapy" by improving diet structure. The consensus points out that green leafy vegetables, bean products, animal livers, lean meat and egg yolks are good food sources of folic acid, and chicken livers (1172.2μgDFE/100g), amaranth (419.8μgDFE/100g), pig livers, sheep livers and soybeans are rich in folic acid. Foods with folic acid content ≥ 120 gdfe/100g (solid) or 60μgDFE/100g (liquid) are "high or rich in folic acid", and foods with folic acid content or folic acid source are half. However, if the absorption and utilization rate of natural food is low, the general population should also take measures such as folic acid supplement or fortified food, and the effective and safe dose is 0.4-1mg per day.

Photographing network

However, it should be noted that long-term large-dose (> 1 mg) folic acid supplementation may cause health risks. Studies have shown that taking more folic acid can mask vitamin B12 deficiency. This deficiency most often occurs in the elderly or people who eat vegetarian food, among which B12 deficiency is more common. Folic acid and B12 are both involved in the production of red blood cells, and the shortage of either will lead to anemia. People who take high-dose folic acid supplements may correct anemia and feel better, but B12 deficiency still exists. In this case, if high folic acid intake continues to "mask" the symptoms of B12 deficiency for a long time, it may cause slow but irreversible damage to the brain and nervous system. In addition, long-term folic acid overdose also has the effects of increasing cancer risk, aggravating neurodegenerative diseases, affecting zinc absorption and reducing immunity. Therefore, it is suggested that if natural folic acid is still available every day, folic acid supplements should not be used more than 400μg per day.

How do special people supplement folic acid?

Pregnant women (including pregnant women)

During pregnancy, folic acid demand will increase due to nucleic acid synthesis. Folic acid deficiency during perinatal period will increase the risk of NTDs, leading to birth defects of fetal spine (spina bifida) and brain (anencephaly). Fifty years ago, no one knew what caused these birth defects. Later, two large trials randomly assigned women to take folic acid or placebo, showing that too little folic acid would increase the birth probability of deformed babies, and getting enough folic acid could greatly reduce this incidence.

In addition, folic acid deficiency during pregnancy may also increase the risk of abortion, premature delivery, stillbirth, megaloblastic anemia, pregnancy-induced hypertension, autism spectrum disorder’s offspring and other diseases.

At present, folic acid supplementation for women of childbearing age is a basic policy in China. The incidence of NTDs in China decreased from 27.4/ 10,000 in 1987 to 1.5/ 10,000 in 2017, a decrease of 94.5%.

The blood folic acid level of rural women in northern China is low. The research results show that this group of people can reach the level of preventing NTDs by taking folic acid 0.4mg/d for at least three months. In addition, many studies suggest that increasing dietary folic acid intake can also reduce the risk of NTDs by about 30%-60%.

Therefore, it is suggested by consensus that women should try their best to take food supplements during pregnancy preparation and early pregnancy, and women in the middle and late pregnancy and lactation can take food supplements and folic acid supplements. It is suggested to supplement folic acid 0.4mg/d or 0.8mg/d from the possible pregnancy or at least 3 months before pregnancy until the third month of pregnancy. The intake of folic acid in the second and third trimester of pregnancy should reach 600 gdfe/d, and it is suggested to supplement folic acid with 400 gdfe/d in addition to food supplement. It is recommended to take 550 gdfe/d folic acid during lactation, and it is recommended to supplement 350 gdfe/d folic acid in addition to food supplement. Personalized supplements are needed for people who live in the north, eat less vegetables and fruits, and have low blood folic acid levels. For women with NTDs reproductive history, diseases such as diabetes, and TT genotype at MTHFR677 locus, the consensus also made tailor-made suggestions.

Cardiovascular disease

The increase of Hcy level caused by folic acid deficiency is considered as an independent risk factor for atherosclerosis and cardiovascular and cerebrovascular diseases. Folic acid deficiency Several large-scale randomized trials of B vitamin supplements to reduce homocysteine levels and prevent heart disease and stroke have not found the benefits of folic acid supplementation. These trials have a similar design: adults with a history of heart disease or stroke or at high risk of heart disease are given pills or placebos containing high doses of vitamins B6, B12 and folic acid. Studies have found that taking high doses of three B vitamins can reduce the level of homocysteine, but it does not lead to a decrease in coronary heart disease events.

However, looking at cardiovascular diseases as a whole may mask the potential benefits of at least one B vitamin, and it may be too late to study people with advanced vascular diseases. An analysis of several studies shows that folic acid supplements can reduce the risk of stroke in people who have not yet had a stroke, but they cannot reduce the risk of a second stroke in people who have already had a stroke.

Effect of folic acid supplementation on stroke risk in preset subgroups

Therefore, it is not recommended to use folic acid to prevent cardiovascular diseases, but folic acid supplementation is recommended for cardiovascular high-risk groups and hypertensive patients with HHcy to reduce Hcy levels. In order to reduce the risk of the first stroke, folic acid monotherapy or fixed compound preparation containing folic acid can be used for patients with HHcy with hypertension. Taking 0.8mg folic acid combined with vitamin B12 daily can achieve the best effect of reducing Hcy.

Neurobehavioral disorders

1. autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which is characterized by difficulties in communication and interaction with others, limited interests and repetitive behaviors. More and more evidence shows that folic acid supplementation during pregnancy may reduce the risk of ASD or reduce the increase of ASD risk caused by prenatal exposure to certain drugs and toxic chemicals. The mechanism of these potential benefits is not clear, but it may be related to the role of folic acid in DNA methylation, which in turn will affect neural development.

Some (but not all) observational studies show that there is a correlation between the use of folic acid and/or multivitamin supplements by pregnant women before and/or during pregnancy and the lower risk of ASD in female offspring. A case-control cohort study of 45,300 Israeli children in 2018 showed that the risk of ASD in children was significantly reduced when mothers took folic acid and/or multivitamin supplements before and/or during pregnancy.

Up to now, the evidence shows that there may be a negative correlation between folic acid intake of mothers during pregnancy and the risk of ASD in their offspring, but there is no evidence to support it in large-scale clinical studies. In addition, some studies believe that children with ASD also have different degrees of abnormal folic acid metabolism due to bad eating behavior, so not exceeding folic acid in these children may be beneficial to the treatment of ASD, but there is still a lack of clinical evidence. Therefore, it is recommended that women of childbearing age should be supplemented with 0.8mg/d regularly to reduce the risk of ASD in their offspring.

2. Depression

Nowadays, depressive disorder has become the second disease in China, with a prevalence rate of 3.02%, ranking first in the total burden of various mental diseases. Some studies have shown that folic acid deficiency is related to depression and low response to antidepressants. The mechanism may be related to the involvement of folic acid in the synthesis of neurotransmitters in the brain. In addition, HHcy is related to depression, and folic acid can degrade Hcy.

In a racial diversity study of 2948 Americans aged 15-39, the concentration of folic acid in serum and red blood cells of patients with severe depression was significantly lower than that of patients who had never suffered from depression. Some clinical studies have shown positive results about whether folic acid supplementation may help depression when used with traditional antidepressants. In addition, the guidelines for the treatment of depression revised by the British Psychopharmacology Association in 2015 and the Canadian network for the treatment of depression and anxiety both recommended folic acid as a supplement to the treatment of serotonin reuptake inhibitors for depression. Therefore, the consensus is that folic acid deficiency is related to depression, and low folic acid level is related to low response of antidepressants. It is recommended that patients with depression should be supplemented with folic acid reasonably on the basis of antidepressants, especially serotonin reuptake inhibitors, and the recommended dose is 0.5-2.5 mg/d.

Cognitive dysfunction

Statistics show that there are 178 million elderly people over 60 years old in China, accounting for about 13% of the total population. There are about 50 million people with dementia and cognitive impairment, and the social burden is huge. Most observational studies conducted so far show that there is a positive correlation between HHcy and the incidence of dementia. Scientists hypothesize that the increase of homocysteine level may have negative effects on the brain through various mechanisms, including the death of neurons caused by cerebrovascular ischemia, abnormal deposition of tau kinase activation and inhibition of methylation reaction.

A Dutch study involving 818 subjects aged 50-70 years showed that folic acid supplementation could reduce Hcy concentration by 26%. Although the cognitive function of subjects declined with age, the folic acid group was superior to the placebo group in memory, information processing speed and sensory motor speed.

Although folic acid supplementation can effectively reduce the level of Hcy, and hypercholesterolemia is an independent risk factor for dementia, based on the current evidence-based medical evidence, it cannot be considered that folic acid supplementation can significantly improve cognitive function. Therefore, the consensus points out that people with cognitive impairment should not advocate long-term use of folic acid without evidence of folic acid deficiency. For those with folic acid deficiency, folic acid 0.8 mg/d can be supplemented (grade C evidence).

kidney disease

Chronic kidney disease (CKD) can lead to Hcy excretion disorder, and dietary restriction in such patients can also increase the risk of folic acid deficiency. Can folic acid supplementation delay the progress of CKD? China’s CSPPT study pointed out that compared with simple antihypertensive therapy, folic acid supplementation of 0.8mg/d can reduce the progress of CKD. But foreign studies show negative results. It is speculated that the difference of research conclusions may be related to the different baseline folic acid levels, that is to say, fortified foods have not been used to supplement folic acid in China, so folic acid supplementation may be beneficial to delay the progression of nephropathy for people with low baseline folic acid levels.

The consensus suggests that folic acid should not be routinely used to delay the progress of CKD, but folic acid supplementation (0.8mg/d) should be considered for patients with folic acid deficiency.

In addition, in the field of cancer, some epidemiological studies show that folic acid intake (or status) is inversely related to colorectal cancer and lung cancer. The exact nature of folic acid on carcinogenesis has not been established, but scientists speculate that folic acid may affect cancer development through its role in carbon metabolism, DNA replication and cell division. Evidence also shows that folic acid may play a dual role in the occurrence and development of cancer. That is to say, folic acid may inhibit some types of cancer in the early stage of development, and taking large doses of folic acid after the establishment of precancerous lesions may promote the development and progress of cancer. We need more research to fully understand how folic acid in diet and folic acid supplementation affect cancer risk, and whether their effects vary with exposure time.

In a word, folic acid is firmly listed in the World Health Organization standard list of essential drugs, and it is one of the most effective and safe drugs needed in the basic public health system. The application of folic acid has achieved great success in improving neonatal malformation, and its application prospect in other fields and disciplines is also very promising. With the deepening of future research, scientists will also find and solve more problems and set more precise guidance for personalized folic acid use.

Note: The content of this article is only for promoting consensus and popular science, and it is not intended to provide personal medical advice.

references

1.Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation.DOI: 10.1056/NEJM199212243272602.

2.Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study.DOI:https://doi.org/10.1016/0140-6736(91)90133-A.

3.Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B12 vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors.doi:10.1001/jama.2010.840.

4.B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial.DOI:https://doi.org/10.1016/S1474-4422(10)70187-3.

5.Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention.https://doi.org/10.1161/STROKEAHA.109.573410.

6.Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring.JAMA Psychiatry. 2018; 75(2):176-184. doi:10.1001/jamapsychiatry.2017.4050.

7.Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.DOI:https://doi.org/10.1016/S0140-6736(07)60109-3.

8. Information on the conference of China Multidisciplinary Expert Consensus on Reasonable Clinical Folic Acid Supplement.

Source: Metz Medical Comprehensive Report

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In the third grade, boys played games for their uncle’s WiFi. cut class squatted in the grass for a day.

　　On the morning of the 2 nd, Ms. Lin, who lives in a community in Longchi Street, Liuhe District, Nanjing, went out early in the morning and found a teenager in school uniform squatting in the grass next to the unit building; When Ms. Lin came home at 5 o’clock in the evening, she still saw the child sitting there, with almost no change in posture. She called him and he ignored him. The abnormal behavior of the teenager worried Ms. Lin, and she called the police for help. The police arrived at the scene and learned that the teenager was a junior three student, and his uncle lived in this building. On that day, he stayed here in cut class for one day to play mobile games on his uncle’s WiFi, which made the mother who came to the scene angry with Ms. Yu.

　　The reporter’s investigation found that the popularity of smart phones and children becoming "mobile phone controllers" have become a common worry for many families. Yangzi Evening News All-Media Reporter Ren Guoyong Correspondent Lu Gongxuan

　　A crazy teenager.

　　Sit in the grass and rub my uncle’s wireless network to play games.

　　Cut class, a teenager, squatted down to numb his legs and feet one day.

　　"There is a big boy I don’t know downstairs who has been sitting in the grass all day. I don’t care if I call him. Come and have a look." At 5 o’clock in the evening on the 2 nd, Ms. Lin reported the police.

　　After receiving the police, the police of Longchi police station arrived at the scene to check that a teenager was sitting downstairs in a unit of the community. He sat under his schoolbag cushion and held his mobile phone intently.

　　"He has been sitting here in this posture. I saw him when I went out in the morning. I didn’t expect him to be here when I came back in the evening. I don’t know what happened. I called him and he ignored me." Ms. Lin said that she noticed that the child was also enthusiastic and worried about what bad things would happen to him.

　　The policeman walked next to the teenager, and he was still absorbed in playing with his mobile phone, unaware that the policeman was approaching. The policeman patted him on the shoulder, and the boy suddenly got up, but he almost fell down because of numbness in his legs and feet. "What are you doing here?" In the face of the police’s question, the child bowed his head and did not answer, only saying that he had something to do.

　　After repeated inquiries by the police, he said that his surname was Cao, and he was in the third grade of a nearby middle school. His uncle lived in this building, and he squatted here to play games on the Internet with his uncle’s WiFi. "I didn’t do anything bad, I just wanted to surf the Internet." He said.

　　Subsequently, the police contacted Cao’s mother. Cao’s mother was surprised when she received the phone call, saying that she didn’t expect her son to go to cut class to play games, and spent a day squatting downstairs in her brother’s house for surfing the Internet.

　　Soon, Cao’s mother rushed to the scene angrily, and immediately scolded him for being unprincipled again and again in order to surf the Internet. Cao’s mother said that her son secretly bought a mobile phone with a birthday red envelope given to him by his elders a month ago. After the parents found out, they criticized him and advised him to return the mobile phone, which was awkward. Later, the parents confiscated the mobile phone, but I didn’t expect him to take it away from his family and come here to play. "He must know that my brother went out these days before he came here to surf the internet. The senior high school entrance examination is coming soon, and he is still so confused."

　　The police also persuaded and educated Cao, and Cao said that he would make up his mind to quit playing mobile phone addiction and prepare for the exam carefully. The police also reminded Cao’s mother to communicate with her children more often, divert his attention from playing mobile phones, and persuade her in time if she has bad habits. After the exchange between the two sides, Cao followed his mother home.

　　Parents’ troubles

　　Smashed the phone, and both girls cried sadly.

　　Do you want to buy it for your daughter now? Mom is very entangled.

　　"I want to use regret to describe my current mood. Now I am in a dilemma!" Ms. Zhang from Laifeng Community in Nanjing told the Yangzi Evening News reporter that her daughter had bought a children’s mobile phone in order to facilitate contact, and she could only answer the phone.

　　But later, my daughter always said that all her classmates used smart phones, and they used smart phones to check their study materials online. Ms. Zhang was hesitant at first. After discussing with her husband, she felt that the times were developing and her daughter’s ideas were reasonable. It might be helpful to use smart phones to access information. Later, I bought my daughter a smart machine with a price of more than 1,000 yuan. After using the smart phone, my daughter quickly played on WeChat and Weibo.

　　"We think there is nothing wrong with sending WeChat Weibo, but now the situation is getting worse and worse." Ms. Zhang said that her daughter’s grades plummeted and the teacher even found her playing mobile phones in class.

　　After discovering the problem, Ms. Zhang began to control her daughter to use her mobile phone. But when my daughter does her homework, she asks her for a mobile phone to consult the information from time to time, but sometimes she finds that she is using QQ or WeChat.

　　Ms. Zhang asked her daughter how to chat? The daughter’s answer is to exchange learning problems with her classmates. In this way, the daughter’s learning efficiency is getting lower and lower. Not long ago, I found my daughter playing small games until the early hours of the morning, and there were novels in the trace of mobile phone search. I clicked and found that my daughter was reading a "messy" article. In this way, the mother and daughter quarreled many times for the mobile phone, and in the end, she smashed the mobile phone.

　　"I smashed my daughter’s mobile phone, and both girls cried. She ignored me for two weeks, and I was heartbroken." Ms. Zhang said that recently, her daughter repeatedly assured her to study hard, proposed to buy a mobile phone again and promised to use it only for consulting materials and communicating with classmates. "I am very entangled, I am afraid to buy it for her, and she can’t control it." Ms. Zhang said.

　　Online small survey

　　Children are forbidden to use smart phones? Not all are objections.

　　In two examples, children have become "mobile phone controllers", which annoys parents. So, at the moment when smart phones are so popular, should children use smart phones? The reporter made a small survey through his circle of friends.

　　Should primary and secondary school students use smart phones?

　　The online survey lasted for one hour, and 51 people voted.

　　A: About 84% are against it.

　　Some parents who indicate the reasons think that underage students are addicted to their opponents’ opportunities, which are difficult to control, and most of them are used for entertainment.

　　B There is one case in which the parents fully agree with the opinion.

　　This parent believes that smart phones are the general trend, otherwise they will be out of touch with society.

　　C about 14% supported by conditions.

　　This part of parents believe that children need to attach conditions to the use of smart phones. If they want to use them, they must know what their children’s purpose is, and it is ok to check the study materials.

　　Teacher’s opinion

　　Every time a parent-teacher meeting is held, many parents complain to the teacher. Children can’t live without mobile phones all day. Should they use them? How can I quit cell phone addiction? Jiang bo, a senior teacher and grade leader of a senior middle school in Nanjing, said — —

　　Even using a mobile phone to check information has great disadvantages.

　　Jiang bo thinks that the only advantage for students to use smart phones is that they are easy to contact.

　　"Access to information is a cover. I found that the questions and answers of some so-called learning software are copied from each other, and there are many mistakes and typos. Students who are used to finding answers online lose the ability to think independently. I strongly appeal to students from primary school to high school to stay away from smartphones." Teacher jiang bo thinks that students who are used to finding answers through the Internet will have a decline in their habit and ability to use reference books, and their learning efficiency is very poor. Usually, they click on a window and another one pops up on the Internet. Students are so curious that they can’t control their reading that they can’t concentrate on completing their homework. Indulging in mobile phones is not good for health, typically, the eyesight drops, and you can only see farther if you look up. Holding mobile phones all day long causes some students to have poor face-to-face communication skills; Some parents are afraid that their children will be out of touch with society without using smart phones. This kind of worry is unnecessary. Mobile phones, like computers, can be learned as soon as they are learned, and there is no need to hold them every day. The mobile phone network has a search function, so it is difficult for parents to monitor whether the content they read is healthy or not.

　　Parents should set a good example for children to quit cell phone addiction.

　　How to quit cell phone addiction? Teacher jiang bo said that depending on the situation, some parents are strong and radical. If they don’t agree to their children’s demands, they will not agree, confiscate their mobile phones and shut down the Internet. Some students have problems in their early education, and their parents have not established an authoritative image at home, and they can’t do the three chapters of the contract. Even if their mobile phones are confiscated and the network is cut off, the effect is not good. Some parents can’t stand the soft grinding and hard foam, but still return their mobile phones to them. When the mobile phone is smashed and the network is closed, it will stimulate such children’s rebellious psychology and stronger curiosity about smart phones. A better way is for parents not to hang their heads all day playing with their mobile phones, but to turn off the home network skillfully, such as changing passwords, limiting traffic, limiting phone bills, and reading famous books on paper. Let children know that mobile phones are just tools and toys, and do not deny that mobile phones are getting more and more fun, but there are more exciting things in life. Parents should take their children to participate in colorful outdoor activities on rest days to divert their attention from mobile phones.

　　● Children’s voice

　　Hungry for respect, disgusted parents smash mobile phones.

　　Yangzi Evening News reporter also communicated with some middle school students. Some students also admitted that mobile phones are basically used for entertainment except making phone calls and finding answers. Sometimes parents will get angry with them after playing for an hour or two.

　　"I am more disgusted with my parents’ tough tone, and it is even more unacceptable to smash my mobile phone." Liu Tong Jr. said that sometimes it was late at night when he was playing with his mobile phone, and he knew that it was not good for him, but the momentum of his father rushing in made people sad.

　　Liu Tongxue Jr. said that even if he made a mistake, he hoped parents could communicate in an equal tone. "Confiscation when you come in is disrespect and distrust," Xiao Liu told reporters.

　　The teacher’s truth is in place, and the child’s voice should also be heard. But have you noticed that children are actually concerned about the same problem at a different level from us adults? They are more concerned about the attitude of parents when dealing with the use of mobile phones than whether they use the mobile phones themselves.

　　Therefore, we want to remind parents that every child has his own personality characteristics, and parents should consider their children’s situation comprehensively, find a communication method suitable for them, and handle this "mobile phone problem" well.

Junyi Digital was increased by 112,000 shares by Shenzhen Stock Connect on March 18th.

K figure 301172_0

On March 18th,obtainIncreased holding of 112,000 shares, which has been increased for three consecutive days, totaling 172,300 shares. The latest shareholding is 1.14 million shares, accounting for 0.93% of the company’s total share capital of A shares.

Data of shareholding in recent five days

Chart of shareholding and stock price changes

Disclaimer: This article is based onProduction, for reference only, does not constitute any investment advice, so the operation risk is at your own risk.

I took a fancy to Changan Auchan A600. What color do you like？

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Changan Auchan A600 has rich color choices, including BMW White, Galaxy Silver, Bright beige, mocha brown, Storm Grey and Junya Red. Each color has its unique charm and temperament, which can meet the individual needs of different consumers.

When I went to book a car, I was lucky to meet a batch of new cars, and all six colors were in stock. I finally chose BMW white, because the white car is not only versatile, but also looks more refreshing and atmospheric. The painting process is also excellent, which makes the car body more beautiful and moving.

On the forum, I saw that many riders also chose Xinghe Silver, which is also very popular. However, the choice of color ultimately depends on personal aesthetics and preferences. Some people may prefer the warmth and comfort of mocha brown, while others may prefer the enthusiasm of Junyahong.

Generally speaking, every color of Changan Auchan A600 has its unique charm. No matter which one you choose, you can find your own uniqueness and personality. Personally, I like BMW white Changan Auchan A600 very much. It’s simple without losing its atmosphere, low-key without losing its taste. It’s a very good car to recommend.

Popular big-name beauty TATCHA, the first store in the national department store, settled in Wulin Yintai and also equipped with a beauty shop.

　　On the eve of the Spring Festival, Hangzhou added the first brand of beauty cosmetics. On January 30th, the first national department store of TATCHA, an international pure luxury skin care brand, opened in Hangzhou Wulin Yintai Department Store. Consumers who love beauty have more choices of big-name beauty cosmetics, and the strength of Hangzhou Wulin Yintai’s "brand first harvester" has been verified again.

　　On social platforms, TATCHA’s purple rice cream, greenMany single products, such as cream and white satin cream, have been called "low-key and luxurious out-of-stock king" by netizens. TATCHA Hangzhou Wulin Yintai counter opened, which not only gathered hot items, but also new products and models, and the limited edition of the Year of the Dragon will all be presented.

　　The reporter learned that on the eve of the opening ceremony, TATCHA’s gold foil soft lip balm set, green cream set and other limited gift boxes became "toon" on the launch of Yintai Department Store Miaojie APP. With the opening of the first TATCHA national department store, Cecilia Han, the brand spokesperson, will come to Wulin Yintai on the eve of the Spring Festival to deliver benefits to Hangzhou consumers.

　　TATCHA counter located on the first floor of Hangzhou Wulin Yintai, with purple as the main color, continues the brand’s immersive pure luxury skin care experience, and is also equipped with a beauty shop, so that customers can enjoy purple quiet time when learning about the brand and trying out products.

　　"Coming to Intime Department Store is a brand-new exploration of our brand in the retail field," said Ms. Cathy Yang, general manager of TATCHA brand. The cooperation with Intime Department Store will be passed.shirt-sleeveWays to attract and serve more young consumers, and at the same time give play to the advantages of Yintai offline shopping malls, so that consumers can experience brands and products in an immersive way. Next, the brand will continue to promote the brand’s landing in many stores in Yintai Department Store.

　　In addition to TATCHA’s first national department store, AVEDA Avanda’s first store in Hangzhou recently opened in Hangzhou Wulin Yintai.

　　According to the relevant person in charge of Hangzhou Wulin Yintai Department Store, on the eve of the Spring Festival, the shopping mall not only welcomed the opening of several first-store brands, but also released dozens of new products and limited gift boxes of the Year of the Dragon with big beauty brands in Yintai. For example, Laura Mercier’s "Dragon Dance Auspicious" carved version of the Year of the Dragon limited vitality glow blush, Bobbi Brown Barbie Brown’s dragon rhyme color New Year limited series and so on. Visit Yintai Department Store during the Spring Festival, and you can also enjoy discounts such as coupons for returning to 150 yuan after spending all your money in 1000 yuan.

2022 Beauty Word-of-Mouth List Releases Top Products throughout the Year, Leading the Beauty Trend

　　The 2022 Sina Fashion Beauty Word-of-Mouth List was announced as a style award list, aiming at establishing industry influence, leading new trends in the beauty field, and providing the public with an authoritative guide to the consumption of beauty products in 2022.

　　The list focuses on six categories of beauty products: skin care, make-up, hairdressing, fragrance, personal care and medical beauty. Recommended by independent brand registration, experts in the beauty industry, etc., and screened by Weibo Big Data, 44 selected products were selected from more than 400 items, and entered the stage of national referendum. Finally, 10 items on the list were produced by integrating Weibo Big Data, netizens’ voting and the opinions of the 100-V jury, ranking in no particular order. Let’s see what good beauty products stand out this year!

　　Skin care articles-

　　In recent years, people’s demand for skin care has become more and more refined, and high-energy efficacy skin care products and ingredient party skin care products have been sought after by everyone. Compared with brands and sales, people pay more and more attention to efficacy and whether it really suits their skin. On the basis of repairing and protecting barriers, they choose skin care products more pertinently.　　

　　Skin care products with anti-aging effect have always been the mainstream of high demand, especially with the anti-aging and rejuvenation, more and more young people join the anti-aging team, and products with anti-aging effect while nourishing skin are very popular. Among them, Whoo Tianlv Dan and Lilv Lotion, which have nourishing, firming and anti-aging effects, stand out, and Dior’s reversal cream has also attracted attention with its breakthrough age-hiding technology.

　　In addition to natural skin aging, skin problems caused by external environment and stress are also worthy of attention. fresh volcanic tea essence can effectively resist the impact of daily stress that causes signs of skin aging and has become the love of migrant workers.

　　Firming and nourishing skin and water emulsion award

　　Whoo

　　Tian Lu Dan and Lu Ti La nourishing liquid+nourishing milk

　　Effectively tighten and lift, and carve the side face. Suitable for people with anti-aging needs such as 28+, decreased compactness and facial sagging. Adopt exclusive luxury ingredients: harmonious complex and Zhengui Sichuan grass flower. Selection of various Dendrobium plants and extractions based on the harmonious and clear complex can effectively improve the moisture density and lifting state of the skin, and endow the skin with full hydration and compactness. The vitality of Sichuan grass flowers, which only blooms one day a year, can effectively solve skin problems such as dullness and relaxation, maintain skin elasticity and sculpt young contours.

　　It absorbs quickly and has a tender and rich nourishing feeling. The texture is refreshing and soft, and the luster is lifted and tightened, which provides deep moisturizing and rejuvenation, and at the same time contributes to the absorption of subsequent skin care products, and luxuriously nourishes dazzling and exquisite skin.

　　Zhuo Xiao Huan Yan Jing Award

　　Fu lei Shi fresh

　　Tea fragrance essence empowering essence dew (volcanic tea essence)

　　Stress attacks in daily life, such as lack of sleep, poor diet and seasonal changes, will lead to signs of skin aging, slow down the energy operation mechanism of skin, reduce the self-protection of skin against free radicals, and eventually lead to the loss of "toughness" of skin: rough skin, fine lines, coarse pores, skin loss of elasticity, dull and dull. Volcanic tea essence can enhance skin toughness, resist the influence of daily pressure that causes signs of skin aging, effectively reduce fine lines and wrinkles, make skin smoother, more shiny and more elastic, and reshape youth.

　　Fresh Frestech Research Laboratory overcomes the cutting-edge cell decomposition and extraction method, and accurately extracts the adaptive phytochemicals in volcanic tea, that is, the high-concentration and precious ingredient APT tea extracts muscle energy to adjust technology, and its function is to revitalize skin cell energy and provide excellent antioxidant capacity. In addition to this powerful tea from Mauritius, the essence of fresh freshi volcanic tea also contains nicotinamide, which can fine pores and even skin; 5kDA micro-molecular hyaluronic acid is used to deeply replenish water and dilute fine lines and wrinkles; Ceramide III strengthens the skin barrier, making it tender and moist; And deep-sea giant algae can delicate skin and improve roughness.

　　Scientific research breakthrough anti-aging cream award

　　Dior Dior

　　Flower secret rose extract cream (reverse cream)

　　Dior Dior Reversing Cream was inspired by glanville rose with extraordinary rejuvenation ability, and combined with scientific discovery, it achieved obvious triple aging effect!

　　Dior Dior Reversal Cream contains compound rose peptides, which promotes the breakthrough of hidden age technology and marks the first step for Dior Dior to enter the field of hidden age. Newly poured compound rose peptide can reduce the signal of cell aging, resist cell aging at the root, and open a new realm of skin aging: 1. Deep aging, stable collagen matrix, 3 times collagen type I, 6 times collagen type VII; 2, shallow age, promoting cell rejuvenation and filling the skin; 3, the surface layer is hidden, promoting ceramide production and strengthening the barrier. 94% of the formula comes from natural ingredients, and its texture is light and silky. It has been carefully controlled by Dior’s six formula steps and different temperatures. Keep the moisture inside the skin, and make the skin stand firm.

　　Make-up articles-

　　New products are constantly changing, and the amount of high-value cross-boundaries is endless. Today’s makeup market is getting more and more volume! To achieve effective makeup, it is inseparable from the really easy-to-use word-of-mouth cosmetics. How to become an explosion recommended by beauty bloggers, easy to use and not picky about skin quality must be the first. In addition, the stylish appearance is also a plus item.

　　This year’s makeup is particularly popular with natural textures, such as boiled water makeup, and the makeup that focuses on natural makeup is easier to get out of the circle. The YSL powder air cushion, which creates the natural beauty of water, has become the top1 of the base makeup category, and the new product of natural fog eyebrow makeup, Bei Lingfei eyebrow pencil, has also become an explosion. Chanel tweed four-color eye shadow 02, which continues Chanel fashion design, also stands out because of its beautiful color matching.

　　Light and flawless air cushion award

　　Yves Saint Laurent ysl

　　Bright colored powder light cushion liquid foundation (powder air cushion)

　　YSL Saint Laurent powder air cushion is packed with cold glacier powder leather and matched with classic Saint Laurent powder gold. Compared with YSL Saint Laurent leather air cushion, the thickness is reduced by one-third, and the lightweight essence is restored. Clean magnetic attraction design, easy to open and take, with an uninhibited posture, always explore the natural makeup feeling.

　　Lightly repeated, it is flawless: it has the concealing power beyond liquid foundation. Cream-like powder cream is evenly powdered through silk micro-mesh, and the powder becomes more and more delicate. The flawless base makeup bid farewell to the massiness, and you can quickly create a perfect makeup by tapping. Water feeling is not sticky: water feeling film-forming technology perfectly balances the proportion of hydration and film-forming. 60%+skin nourishing essence’+’respiratory protective film’, which can wrap the skin easily, instantly moisturize, refresh and not stick. Clean powder light: YSL powder air cushion adopts three-dimensional light-chasing technology. Just as the first ray of sunshine at sunrise shines on the face, the skin is awakened to be born bright. In an instant, the sense of neatness is clear, and the powder light appears.

　　Fashion design eye shadow award

　　CHANEL Chanel

　　Tweed four-color eye shadow color number 02(TWEED eye shadow)

　　For Chanel brand, tweed is full of infinite possibilities, which brings unparalleled creative freedom and deduces endless shapes, colors and styles. Chanel Makeup Creative Studio draws inspiration from this brand’s iconic fabric to create the 2022 eye makeup series. The style essence of tweed is once again interpreted in a new way, and it is limited to creating four-color eye shadow!

　　Tweed, woven eyes look beautiful. The new 2022 eye makeup series introduces four limited creations, and the surface of each tone is decorated with textured relief patterns of tweed. Four groups of harmonious color matching vividly show the characteristics of fabrics. Just as tweed is woven with numerous and varied silk threads, the color of eye shadow can be adjusted and matched, and it is suitable for shades, giving a fashionable and bold makeup effect. Pink and lavender with different shades of color number 02 wander between softness and beauty, creating a gorgeous makeup with luster like satin.

　　Natural texture eyebrow pencil award

　　Bei lingfei benefit

　　Automatic meniscus eyebrow pencil at every moment of eyebrow.

　　Point-line-surface to create a variety of velvet fog eyebrows-"one multi-purpose": point, meniscus eyebrow pencil nib, to create root hair flu. The line, the inclined plane of the meniscus eyebrow pencil, fits the curve of the eyebrow, and the pen becomes a front. Face, the pen face where the curves intersect, naturally develops color and fills the gap between the eyebrows, forming a velvet eyebrow.

　　Hairdressing articles-

　　Hair loss, king of hair volume and fluffy feeling are the most frequently mentioned words in recent years. Shampooing is no longer a simple cleaning process, but pays more attention to the maintenance of scalp hair quality. With its refreshing and abundant strength, Swarovski fluffy pink bottle has become a one pick for netizens.

　　Exquisite and abundant care award

　　Schwarzkopf

　　Fengying Tough Care Series (fluffy powder bottle)

　　There are many possibilities of "healing" beauty by lifting the flat seal. Schwartz fluffy pink bottle specializes in developing root standing technology to relieve the three flat seal inflammation, and let it be "beautiful" for a day, with full charm! Let the people with greasy and flat scalp feel relaxed and carefree, let the people with soft and flat hair feel strong and confident, and let the girls with fragile and flat hair feel comfortable and beautiful.

　　Fragrance articles-

　　Perfume represents everyone’s temperament, taste and mood. Nowadays, a small number of fragrances have sprung up in the fragrance market. People pay more attention to personality, attitude and sense of story when choosing perfume, and place more emotions on perfume. The Valentino Day Rose, which shines with confidence, charm and gorgeous self, is such a bottle of fragrance with attitude.

　　Extraordinary charm perfume award

　　Valentino Valentino

　　Lovers perfume day rose

　　The brand-new Valentino couple perfume, White Rose, is an exclusive rose garden for Valentino women, and it is also a colorful business card for daydreamers who are born and gorgeous. The top note of perfume is paved with hand-picked bergamot in Calabria, southern Italy, which awakens the senses with its rich aroma and collides with the vitality and enthusiasm of fiore lemon in primo, Italy, adding fragrance. Litchi is sweet and mixed with citrus fragrance, sweet but not greasy. The middle tone of perfume is the home of roses. Extract thousands of rose essences, seal them in bottles, and restore the most authentic rose shadow. In the tail tone, the white musk with skin texture and the fragrant Damascus rose blend dreamily, and the pure soap fragrance and sweet charm are intertwined layer by layer, as if blossoming roses in the body, blooming with extraordinary confidence and charm from the inside out.

　　A protective article-

　　Exquisite girls can not only look at their faces, but also care for the whole body, especially delicate lips. Hailan Mystery Lip Moisturizing Cream won the first place in the category of care products with its excellent use experience and repair effect.

　　Soothing lip cream award

　　Blue mystery LA MER

　　Lip cream

　　Sea Blue Mystery Repair Lip Cream is unique in mint fragrance, moisturizing and repairing, cool and soothing, with a touch of repair and drying, which keeps lips soft, fresh and lasting moist, lights up the moist and radiant lips, and with the sweet breath like mint chocolate, lips are tender and shiny.

　　Medical beauty articles-

　　With the diversification of ways to change beauty, people pay more and more attention to the medical beauty industry, and the people who consider medical beauty develop from a very small group to the general public, especially the non-surgical "Light medical cosmetology". Medical beauty is not only a way to improve facial defects, more and more people choose to make their skin better through Light medical cosmetology project, and Light medical cosmetology has become a common skin improvement step as well as skin care.

　　In choosing medical beauty projects, besides considering formal institutions and professional doctors, a medical beauty product with full sense of technology, safety and peace of mind is also very important. Restylane Dingcai cross-linked sodium hyaluronate gel for injection is well recognized by consumers.

　　Innovative technology medical beauty award

　　Restylane Dingcai Restylane Defyne

　　Cross-linked sodium hyaluronate gel for injection (OBT dynamic hyaluronic acid)

　　Restylane Dingcai Restylane Defyne cross-linked sodium hyaluronate gel for injection, using the new OBT gel technology, has performed well in supporting and shaping. It is used to improve moderate and severe nasolabial groove, and provides a solution for maintaining dynamic natural facial expression and facial shaping by virtue of its excellent supporting force and stretching force.

　　Restylane decided to adopt the unique OBT excellent balanced gel technology, which has both G’ value and xStrain value of hyaluronic acid gel, so that it has excellent molding force and tensile force. Dynamic modeling, blooming. At the same time, it is also the first hyaluronic acid in the world to use five dynamic expressions to evaluate the effect after injection, and 97% of the subjects feel that their smiles are more touching. Highly satisfied with the natural effect, 95% of the subjects were satisfied with the natural effect after injection.

　　Ok, the complete list of 2022 beauty word-of-mouth list is here. Please continue to pay attention to Sina Fashion # Beauty Word-of-mouth List # for more exciting!