分类： gfthgyj

　　In the past two years, the competition in the domestic smartphone market has become more and more intense. In addition to the serious inversion in terms of performance and performance configuration, various mobile phone manufacturers have also made more and more innovations in the appearance design of mobile phones, and they have become more and more beautiful and fashionable. For example, the appearance design of the Meizu 20 INFINITY Unbounded Edition that has just been listed in the past two days feels quite outstanding.

　　Zhizu GQ recently launched a fashion short film. This time, it joined hands with Meizu to launch the "Meizu GQ Boundless Fashion Blockbuster". This short film fully demonstrates the fashionable appearance design of Meizu 20 INFINITY Boundless Edition, highlighting the fashion and elegance that Meizu 20 INFINITY Boundless Edition brings to users. In addition, Meizu 20 INFINITY Boundless Edition provides three color schemes: Nebula Green, Space Silver, and Star Black. Each color scheme has a unique texture.

　　First of all, in terms of the body material, the Meizu 20 INFINITY Unbounded Edition uses the industry-leading double-sided Meizu Titan glass, high-strength double-glass-ceramics material, which not only improves the anti-drop performance of the mobile phone by 4 times, but also makes the phone more integrated and delicate. Moreover, on the front of the fuselage, the Meizu 20 INFINITY Unbounded Edition uses "Infinite Design" as the design language, the front screen has a 2.48mm four-level extremely narrow frame, and with a small hole front lens, the screen ratio has been achieved by 91%. The middle frame is also made of "hybrid ultra-lightweight stainless steel" material, which not only weighs 30% less, but also increases the heat dissipation efficiency by 40%.

　　Of course, in addition to being full of technology in the front and frame design, the design of the rear lens module of the Meizu 20 INFINITY Unbounded Edition is also quite excellent. Three high-quality rear lenses are arranged on the straight back of the mobile phone, and on each lens, Unibody unbounded sapphire lenses with hardness comparable to diamonds are covered to avoid scratching the lens, which improves the aesthetics and practicality of the lens.

　　In terms of configuration, Meizu 20 INFINITY Unbounded Edition, as Meizu’s current super-large cup flagship, maintains the current first-tier level of performance. It is equipped with the Snapdragon 8 Gen 2 flagship processor, LPDDR5X memory and UFS 4.0 flash memory. With the support of the new Flyme 10 system, it can provide users with strong performance support and smooth operation experience. In terms of battery life charging, the built-in 4800mAh battery supports 65W Super mCharge wired overcharge technology, making the charging battery life of the mobile phone even better.

　　As the future exploration flagship of the Meizu 20 series, the Meizu 20 INFINITY Unbounded Edition carries Meizu’s pursuit of unbounded aesthetics. With leading technology and materials, it integrates technology and art unbounded. It is an aesthetic peak of "beyond the bounds, take the sky". If you are considering changing to a flagship phone with excellent design and top configuration in the near future, then the Meizu 20 INFINITY Unbounded Edition is worth considering.

　　Consumers who pay attention to protecting personal rights and interests can hardly miss the annual "Spring Festival Evening"-315 party.

　　However, from the moment the TV is turned on, the rights and interests of about 300 million consumers in the country have been infringed-dozens of seconds of on-off advertisements.

　　This is a long-standing "stubborn disease" in the smart TV industry, but there is a trend that bad money drives out good money, and manufacturers "fall" one by one. Not only on the "315" Rights Protection Day, in the past days, many consumers have continued to complain.

　　"Watching TV was originally relaxing. As a result, I watched the advertisement first, and I couldn’t turn it off. I escaped the advertisement of the mobile APP, but I couldn’t hide here. What is even more frightening is that the advertisement is getting longer and longer. At first, it takes more than ten seconds, and then it takes dozens of seconds and one minute. At this time, a sprint race may be over. "

　　On the social media platform, consumers can often see all kinds of complaints about smart TV on-off advertisements: whether it is sports fans who are anxious to watch the live broadcast of the game, children who are waiting to watch cartoons, or middle-aged and elderly users who are not familiar with the network, the bad experience that on-off advertisements can’t be skipped is a refreshing of the lower limit of endurance again and again.

　　No wonder, some people miss the old TV in the past, and they can turn it on and off with one click.

　　Smart TV, which integrates the rich content of the Internet, should not be so complicated, let alone make people wait too long.

　　It’s International Consumer Rights Day on March 15th, and the theme of this CCTV 3.15th party is "Fair, Honest and Safe Consumption", that is, fair, reasonable, equal and safe consumption. On-off advertising allows consumers to passively accept what they don’t want to see, which is contrary to fairness and integrity, and it doesn’t matter if they feel at ease.

　　On-off advertising, why become the "psoriasis" of smart TV?

　　Before the popularity of smart TV, the boot mode in our memory is very simple and rude. Pick up the remote control on the coffee table and you can boot it with one button.

　　But in the era of smart TV, after some TVs are turned on, it is not TV programs that jump out, but advertising content ranging from a few seconds to dozens of seconds. When the user just found the button to turn off the advertisement, the advertisement was finished.

　　Smart TV manufacturers have earned another advertising click fee. For the audience, the so-called intelligent technology did not bring the beautiful experience it deserved.

　　On a consumer service platform, key words such as "TV, startup advertisement" were entered, and 172 results were found.

　　Some users said that after buying the TV at first, it was a one-button switch, and there was no advertisement; After a few months, TV not only suddenly extended the on-off time, but also appeared a 15-second on-off advertisement.

　　In addition, some consumers complain that on-off advertising seems to have an extended trend. "I endured it in the first 10 seconds, but now it’s 15 seconds to 20 seconds. Every time I turn it on and off, it’s like being forced to watch an advertisement, which is getting more and more annoying."

　　In fact, before users buy smart TVs, some salespeople are reluctant to take the initiative to tell the system to pre-install information such as "on-off advertising" in order to sell products. Some manufacturers responded after receiving consumer complaints, and the on-off advertisement was pre-installed in the system and could not be cancelled.

　　Article 44 of the Advertising Law clearly states: "Publishing and sending advertisements through the Internet shall not affect users’ normal use of the Internet. Advertisements published in the form of pop-ups on Internet pages should be clearly marked with a closing sign to ensure one-click closure. "

　　But the reality is that users have searched for a long time in the system settings, but they have not found the function of closing advertisements.

　　Some consumers even said that a lot of advertising information is extremely misleading. "The information conveyed by many on-off advertisements doesn’t seem to be very reliable", which is easy to fall into the "trap" of on-off advertisements for some elderly viewers with weak awareness of prevention, who have just left the exaggerated TV shopping bombing of traditional TV.

　　The negative impact of on-off advertising can be small, but in any case, it should not be the reason for consumers to resist smart TV, nor can it become an obstacle to the orderly and healthy development of smart TV industry. The reason behind this "psoriasis", which has been repeatedly concerned by the regulatory authorities and repeatedly exposed by authoritative media, lies in the high advertising profits.

　　Manufacturers earn 2.6 billion advertising fees a year, and consumers are "bonus hunter"

　　With the rich Internet content ecology and the massive investment of technology companies, the smart TV market has maintained rapid growth.

　　At present, the number of domestic smart TV users has exceeded 300 million, and it has a tendency to continue to expand. Smart TV has long been a regular item at home.

　　In the early days when the Internet invaded traditional industries, it was often necessary to capture a large number of users through lower prices. As a result of price reduction, consumers have made a profit on the price, but relatively speaking, the profits of manufacturers have changed from thick to thin.

　　The so-called "wool is on the sheep", and the profit has become thinner. Where can we make up for it? As a result, "on-off advertising" was targeted in this way. What’s more, individual manufacturers have embedded advertisements in the dazzling TV UI interface.

　　According to statistics, the scale of domestic Internet advertising was close to 550 billion yuan last year, and system advertising, including on-off advertising, could bring 2.6 billion yuan in revenue to related manufacturers.

　　In October 2021, the "Pain Point Report of Big Screen TV" released by consumer reports showed that on-off advertising has become the "number one pain point" for consumers. Regarding the bad reviews of advertisements, consumers focus on three aspects: poor experience, long time and inability to close. Of all the domestic and foreign TV manufacturers surveyed, only Samsung, Panasonic, Sony, Glory and LG have no advertisements.

　　Then, the People’s Network Finance and Economics Research Institute released the "Research Report on On-Off Advertising of Smart TV in 2021". Relevant data also pointed out that advertising has seriously affected the consumer experience. More than 89.9% of the respondents said that their smart TVs contained "on-off advertisements", while only 10% did not.

　　86.1% of the manufacturers did not set the "one-button cancel/close button" for on-off advertising; 84.9% of the respondents only advertised the existing switch-on and switch-off when they used it, and only 9.6% of the respondents knew it before buying it.

　　It is worth mentioning that the data shows that the five most important items for respondents to choose smart TV are image quality, price, after-sales service, whether there are on-off advertisements and sound quality, accounting for 85.3%, 72.2%, 59.1%, 55.6% and 49.5% respectively. Whether there are on-off advertisements has become a very important factor for consumers to choose products.

　　This mode of making money is a "bonus hunter" from consumers, which not only damages consumers’ experience of watching TV, but also allows pervasive advertisements to break into family space.

　　Distorted profit model, while trampling on consumers’ rights and interests, does not forget to pour "cheap" dirty water on consumers. In fact, without discussing the high-priced products of Sony and other manufacturers, the price of glory smart screen without advertising is lower, and it has won many times in the objective evaluation of scientific and technological media.

　　Manufacturers can’t be "fair and upright", how can consumers "consume with peace of mind"?

　　According to the latest data released by Aoweiyun. com, in February this year, the scale of online retail sales of color TVs decreased by 17.6% year-on-year.

　　There are many reasons for the decline in smart TV sales, but the bad experience is not innocent, including on-off advertising.

　　As a product whose right to use has completely belonged to consumers, it is up to consumers to decide what to see, what to experience, and whether there can be on-off advertisements.

　　Science and technology are good, and the initial heart of TV practitioners cannot be changed.

　　The change of science and technology has produced more cool products, but the service and experience have not changed with it. When TV manufacturers only pay attention to the profit of technology and ignore the user experience, technology loses its initial intention of creating a better life.

　　Consumers will eventually vote with money, support products that pay more attention to user experience, and let good money drive out bad money.

　　On the other hand, in the domestic TV industry, we need manufacturers like Glory to dare to break the chaos in the industry and "run backwards".

　　In an exclusive interview with the people’s living room last year, Zhao Ming, CEO of Glory, said, "We are the first enterprise in China to put forward the idea of switching on and off without advertisements, and we are also one of the manufacturers that still insist on switching on and off the smart screen without advertisements. The core value of our enterprise is to take consumers as the center." Impressed many people.

　　It is not easy to insist on no-switch advertising. On-off advertising chaos has been repeatedly banned because it has indeed brought many benefits to many manufacturers. On the other hand, glory, "I will never move", from the creation of the smart screen category in 2019 to the present, I have been practicing the concept of "no advertising on and off".

　　For example, the X2 series of Glory Smart Screen released in September last year, in addition to continuing the feature of no advertisement on and off, has also performed well in terms of product strength such as sound quality, multi-screen collaboration and smart interconnection.

　　Good products can talk. At the 7th Responsible Consumption Forum, Glory Smart Screen won the "2021 Responsible Product Award" as a new product in the industry with its "customer first" values, excellent technical level and product quality.

　　The so-called responsible consumption means that consumers should make their consumption behavior have a positive impact on their future lives and adopt a "responsible" attitude in the process of consumption, so as to promote production and provide products that are more in line with the health and long-term development of the industry. Obviously, the screen of glory and wisdom can afford it.

　　As a pioneer who leads the trend of no advertising in the industry and a fellow traveler who thinks about consumers, turning on and off the glory smart screen without advertising is only the first step to be fair and upright, so that consumers can spend with peace of mind and promote the improvement of science and technology, and more TV manufacturers need to participate in it. The road ahead is long and there is a long way to go.

　　The parking problem in the hospital has been bothering many car owners who go to see a doctor. In order to find a parking space, they often spend a lot of time, which also causes traffic congestion in the area. In order to solve this dilemma, on the 16th, the traffic police department of Nanning, together with the First Affiliated Hospital of Guangxi Medical University, e-driver and other related enterprises, took the lead in piloting the "parking service" paid service in the First Affiliated Hospital of Medical University. Citizens who came to see a doctor can enjoy this service by scanning the code and placing an order. Parking service charges 39 yuan service fee every time, and the parking fee is free for the first two hours, and then charged at 2 yuan per hour. (Nanning Evening News, May 17)

　　Nowadays, there are more and more cars in the city, and it is more and more difficult to park, especially in places like hospitals. The peak hours of queuing for parking often last for several hours. The "parking service" service makes parking easy. You don’t need to find your own parking space at all, and you don’t need to waste time because of parking. You only need an APP and a WeChat applet to get it easily.

　　However, as a new business, it has both advantages and disadvantages. Although the "parking service" using the Internet is simple, many apps not only record the user’s name, gender and age, but also record various information of the user’s vehicle in detail. Once leaked, it will bring opportunities to criminals. Moreover, the situation that netizens are worried about does not rule out: what if the driver directly drives away? If there is a collision or a trivial matter, and the driver has an accident, how should the responsibility be divided?

　　These worries and concerns are not superfluous. Conflicts and disputes caused by "parking service" have occurred from time to time in some places. According to media reports, in 2017, Mr. Luo, the owner of Foshan, drove to Guangzhou Baiyun Airport. Considering that parking at the airport was relatively expensive and inconvenient, he tried to choose an "e-parking" company to let the parking driver choose the surrounding parking lot for himself. Two days later, Mr. Luo came back from a business trip. Unexpectedly, his car "ran" for 400 kilometers for no reason.

　　Although the car service originated from the Internet platform is an innovative model, it is an internal behavior of enterprises and companies. At present, there is no special relevant regulation in China, which is easy to damage the interests of consumers. Therefore, as a new thing, "parking service", both the owner and the service provider need to be cautious. For parking service companies, they should have strict driving experience and driver’s license requirements for parking drivers, and strengthen daily management and supervision. For car owners who try the "parking service" service, they must take the initiative to confirm their certificates, identities, etc. when handing over their vehicles to the parking driver.

　　More importantly, the relevant functional departments should keep pace with the times, face up to the loopholes and potential safety hazards in this emerging industry, and regulate it from the aspects of industry license, qualification examination and change filing on the basis of strengthening self-discipline of merchants. For example, businesses are required to display the driver’s license, certificate of approval and job responsibilities of parking drivers in obvious positions, and how to take responsibility after problems occur, and formulate standardized ways to manage vehicles and keys, and at the same time introduce corresponding laws and regulations for effective supervision. (Fu Biao)

Fast technology April 26 news, recently Geely Automobile officially announcedAppoint the well-known car critic "Speed Partner -Jacky" as the global ambassador of Geely Emgrand..

Other people’s ambassadors are all looking for various stars. Why does Geely let a car critic take this responsibility? -Jacky, the speed partner, also explained it in the released video, starting with his own purchase of a plug-in hybrid version of Emgrand L.

When the Emgrand L plug-in version was just launched, he bought one at his own expense, and then was impressed by its power system and chassis, and completely fell in love with this inexpensive car.He has repeatedly expressed his praise for this car on social platforms such as Weibo, and used love to generate electricity. The cumulative publicity times exceeded 110 times..

At the end of December last year, Yang Xueliang, senior vice president of Geely Holding Group, noticed this and said that he would go to Hangzhou to sign an Emgrand spokesperson.

Two days ago, after the listing of Krypton 009 Brilliant, "-Jacky" forwarded it to Weibo of Yang Xueliang, saying that he really liked this car, and proposed that the endorsement fee for Emgrand for life was a Krypton 009 Brilliant. This proposal was recognized by Yang Xueliang, and he was asked to draw up a contract to sign at the Beijing Auto Show.

As soon as the red mouth and white teeth came out, it was natural to implement them. Just taking advantage of the opportunity of the auto show, "Speed Partner -Jacky" found Yang Xueliang at the Lotus booth.The latter put his endorsement into practice and fulfilled his promise.This is the official announcement of Geely.

　　 At the beginning of the year, the glory version of BYD Qin PLUS and the glory version of destroyer 05 were sold from 79,800. At the same time, the price entered the era of "7", and it also had a higher configuration than the fuel vehicle of the same class, which truly achieved "both want and want". This is tantamount to dropping a bombshell on the automobile market in China, and it also shows that in 2024, BYD will no longer "show mercy" on fuel vehicles, and in order to speed up the conversion from oil to electricity, it will launch a "general attack" on joint-venture fuel vehicles at the beginning of the year.

　　Why BYD?

　　 In the impression of many people, new energy vehicles are more expensive than fuel vehicles of the same level, and at most they are oil level rights. But this time, BYD’s two glory models have achieved "electricity is lower than oil" and the price reduction is not reduced. Why can BYD do it?

　　 The first is the core cost advantage.

　　 In 2023, BYD sold a total of 3,024,400 vehicles, up 61.9% year-on-year, which is not only the annual sales champion of China automobile market, but also the global sales champion of new energy vehicles. The annual sales volume of more than 3 million not only set a record for China automobile, but also made BYD the first China automobile enterprise to enter the top ten in the world.

　　 Matching the sales growth, BYD’s huge R&D investment has exceeded 100 billion, with over 90,000 R&D engineers and 11 technical research institutes. At present, BYD has accumulated a huge and systematic "technical fish pond" and applied for over 6,700 patents in 2023 alone.

　　 On the surface, it is the price war of products, but in fact it is the system war of industries. The scale effect and the advantages of the whole industry chain give BYD the initiative in product pricing. Ultra-large-scale sales, combined with its own cost control ability and strong technical strength, make BYD have the ability and strength to show sincerity in the price of new cars, give more benefits to consumers, and let consumers really feel the dividend of BYD’s development.

　　Promote the popularization of new energy vehicles

　　 As a leader of new energy vehicles, BYD has been practicing its brand concept with practical actions.

　　 The launch of 79,800 glory models this time is a direct embodiment of this concept. As the first car company to achieve lower electricity than oil, plug-in hybrid is lower than the price of fuel vehicles. This has also become a watershed and milestone in the development of automobile categories, further improving the penetration rate of new energy vehicles and consolidating and strengthening the leading position of China brand in the A-class sedan market. The lower use cost, plus the exemption from licensing and reduction of purchase tax, makes fuel vehicles no longer have a price advantage in front of them. BYD’s intention is obvious, so that more and more consumers can afford new energy vehicles and are willing to buy new energy vehicles, thus promoting the popularization of new energy vehicles in the China automobile market.

　　 In the new energy vehicle market, BYD’s influence and appeal are beyond doubt. The launch of the Glory version of the vehicle further demonstrates its strong technical strength and cost control ability. In addition to allowing consumers to buy better new energy vehicles at more realistic prices, it will also promote the innovation and progress of new energy vehicle technology in China and promote the product upgrading of the whole industry.

On November 28th, 2017, Anting Shanghai International Automobile City, Automobile Innovation Port, Intelligent Networked Automobile Industry Technology Joint Innovation Center (UIC) and China Automobile Innovation Incubator Alliance (CMIA) jointly released the "Star Plan" to encourage innovation and entrepreneurship in the automobile field, aiming at supporting the demonstration and application of new technologies and models in the automobile field through the integration of resources such as policy subsidies, R&D space, test sites and commercial landing platforms. The conference was held in Shanghai Intelligent Networked Automobile Industry Demonstration Base-Automobile Innovation Port, and the first batch of candidate projects for the finalist plan were announced.

After more than ten years’ construction, Shanghai International Automobile City has built a whole automobile industry chain, including vehicle manufacturers, various parts manufacturers and scientific research forces represented by Tongji University. Under the general trend that the automobile industry is upgrading towards electrification, intelligence, internet and sharing, the development direction of the new stage of automobile city is transforming from traditional automobile research and development, manufacturing and trade to new energy and intelligent networked vehicles, and vigorously supporting the formation of innovative and entrepreneurial clusters;

In terms of new energy, since 2011, Shanghai International Automobile City has become an international demonstration city for electric vehicles. After six years of exploration, it has achieved commercial achievements such as product demonstration, data center and shared time-sharing lease of new energy vehicles.

In terms of intelligent network connection, since the Ministry of Industry and Information Technology awarded China the first pilot demonstration area of intelligent network connection vehicles in June 2015, Shanghai International Automobile City has built a closed test area, an automatic driving scene library and the first V2X test intelligent road, and established the executive body of the demonstration area-the intelligent network connection automobile industry technology joint innovation center.

In the next five years, Shanghai International Automobile City will start the fund to build the city and promote the city, integrate social capital, and invest 200 million yuan to set up special funds for the demonstration and application of new technologies and new models, and grant subsidies to 100 projects successfully selected for the "Star Plan". Projects with new technologies and new models that belong to the field of "new four modernizations" of automobiles and are in the demonstration application stage can be approved after declaration and examination, and can receive financial subsidies worth 30% of the total project investment.

In addition, the plan will also rely on the ecological environment of Shanghai International Automobile City’s global intelligent networked automobile industry highland, integrate superior resources such as office space, test sites, technical talents, and upstream and downstream cooperation platforms in the industrial chain, fully support these outstanding innovation forces and industries, and accelerate the whole process from joint research and development to commercial demonstration and promotion.

The first test of "Smart parking service" in China-it is very important to find the right scene for the commercialization of smart driving.

After the press conference, the first joint R&D achievement-China’s first "Smart parking service" project, which was jointly completed by several short-listed enterprises, was publicly displayed in Auto Innovation Port, and the on-site road test and detailed technical interpretation were carried out. The project was initiated by Auto Innovation Port and is responsible for overall coordination, bringing together leading domestic technical forces such as automobile manufacturers, technology startups and universities to complete it, which has attracted the expectation and attention of the whole industry.

"Smart parking service", simply put, is to press the parking instruction on the mobile App, and the vehicle can automatically enter the underground parking lot from the alighting area through the ground road, and find its own free parking space to park; When the owner needs to pick up the car, he will issue an instruction from the App again and pay the parking fee, and the vehicle will automatically return to the boarding area. There is no one involved in the whole process, which is a typical low-speed unmanned application scenario within a limited range. Since last year, Auto Innovation Port has been planning a one-click parking project, and has conducted joint research and development and demonstration operation of intelligent parking service with six teams from Chery New Energy, Horizon, Tongji University, Jilin University, Shanghai Yiqu and Yilian Technology, expecting to find the first commercial application scenario of intelligent driving. The first road test of the project on November 28th officially demonstrated the research and development achievements of the first phase of the Smart parking service project.

Dr. Jian Xu, Executive General Manager of Shanghai International Automobile City Development Co., Ltd. said that the Smart parking service Project has firmly grasped the pain points of users in the last mile of urban traffic, and it is a promising smart driving scene in the industry at present, because it not only solves the problem of parking difficulties for car users, saves them time, but also greatly improves the efficiency of parking lots and urban management and increases the utilization rate of parking spaces, which can be described as killing two birds with one stone. However, how to move from technology research and development to commercialization requires more participation. At present, Auto Innovation Port has been planning the second phase of the Smart parking service project. The first goal is to expand the number of participating models and vehicles by adding more cooperation with more OEMs, and propose a more general vehicle-end solution; The second is to add more field application scenarios, solidify the environmental transformation technology, and form a parking lot standard suitable for driverless parking; The third is to optimize vehicle scheduling control, improve operational efficiency through cloud platforms and big data decisions, help customers better solve parking pain points, and provide smart city solutions for cities and communities.

　　praise

　　● Fashionable appearance.

　　● The space is large enough and practical.

　　● The safety configuration is relatively neat.

　　● Excellent power control.

　　bullet

　　● The shift lever has no driving feeling.

　　● Power comes slightly slower when accelerating rapidly.

　　As a Mercedes-Benz medium and large RV, this E-Class, which was officially released in 1984, has always been the leader of new technologies in the industry. In fact, its E is the first letter of German Einspritzung (fuel injection technology), because it is the first production car adopting this technology. At the test drive site, the organizer showed us the historical stories of Mercedes-Benz E-Class passed down from generation to generation. Behind every classic gene inheritance are the painstaking efforts of the royal designers.

　　There are two outstanding features of the latest generation: one is the addition of an electronic warning system for driving fatigue, and the other is that the length of the car is 12mm longer than that of the previous generation and the wheelbase is 20mm longer. Of course, the brand-new configuration of the engine and the application of the 7-speed gearbox make this car not only a car for passengers, but also a car for drivers.

　　Appearance: fashion elements are embedded in the classic car body.

　　This model, which was first launched at the Shanghai Auto Show in China, was once rumored to have absorbed some design elements of other luxury cars, but when it was seen, these claims naturally fell apart. When the reporter asked Mr Haller, the designer of the car who ate at the same table, whether he would consider drawing lessons from other people’s excellent factors when designing the car, Mr Haller simply said "Never". He went on to explain that it has always been to lead rather than learn from others. Based on this, the new E-Class combines the classic elements of E-class, the characteristics of M.Benz’s new generation family and the outline of lines. At first glance, it is not only atmospheric, but also very sporty. From the four-eye diamond headlights, V-shaped headstock and deep high waistline transplanted from Fascination concept car to the arrangement of wedge-shaped body and horizontal taillights, it has fully demonstrated the streamlined and avant-garde high-performance style, so the drag coefficient is as low as 0.25 except for the lean figure with C-Class, and therefore this generation of cars has returned to the design of W124 with double doors, convertible and other derivative cars.

　　Interior: concise and practical

　　Compared with some fancy interiors, the interior design of the new E300 is simple and practical. Sitting in the car, you will find that the Command control key greatly simplifies the cumbersome design of the center console in the past. Smooth and sharp lines are everywhere, the sub-gray color scheme is harmonious and eye-catching, and the circular sports/comfort mode button on the armrest is very easy to use. In addition, all the cars currently on sale are equipped with navigation display screens at the top of the center console. Both the control keys and the image display are clear and logical, so although there are many buttons, they are not messy. Massage seats that can be heated or cooled are very comfortable, which is our favorite configuration when conducting long-distance tests. Of course, even ordinary cars are enough to ensure that you can travel comfortably.

　　Space: spacious and comfortable

　　In terms of internal space, the further increased body size provides a more comfortable driving environment for passengers, and with two-stage panoramic sunroof, the internal space is more spacious and bright. The newly equipped ambient lighting system has a five-level brightness level, which can not only provide lighting for the whole car, but also create a relaxed and quiet sense of luxury during travel. Elaborate interior colors and materials not only arouse the psychological resonance of drivers and passengers, but also have unparalleled practicability. In addition, the newly developed reversing video system and rear entertainment system (E300 fashionable standard equipment) not only enable drivers to park easily, but also enable rear passengers to enjoy a more pleasant ride experience during long-distance travel.

　　Power control: excellent work

　　The E300 is equipped with a 3.0-liter V6, the output power can reach 170 kW /230 HP, and the maximum torque is 300 Nm. With Mercedes-advanced 7G-TRONIC seven-speed automatic transmission, the whole shift process is smoother and there is no hysteresis, which makes the E300 have excellent handling performance.

　　During the test run, some young people always compare E300 with it intentionally or unintentionally after occasionally trying some sports cars with a capacity of more than 4.5L or coupes with larger displacement. The conclusion of the comparison must be that almost all cars on the market are under-powered. This is the result of inexperience and blind comparison, and of course, it is also in their conclusion. In fact, the E300 is equipped with a new customized displacement and output power after abandoning the previous generation of supercharge, so the power output is linear in stages, which is imperceptible without careful understanding. The result of the actual operation is that in the starting and accelerating stages, even if the tachometer pointer does not rise rapidly, the car has started easily and shot out immediately. After 2500 revolutions, the power of the car began to approach the peak slowly. At this time, the power is continuous. Whether it is accelerating overtaking or slowly fueling, the car is running in an orderly way. In addition, when driving at a constant speed, the noise of the car is very low, and the sound insulation effect is better than that of the previous generation. However, if the oil supply is too large, it will produce annoying and monotonous noise, and the tail throat sound is not very good. The response rate of both the automatic seven-gear gearbox and the shift paddle is ok, and the gear ratio design of the second and third gears is also very ideal. Because the body is heavy and the chassis is extremely solid, even if the speed is 160 kilometers, the car still runs steadily, and its control can be seen.

　　If we really want to find the shortage, it is that when the speed is 80-90 kilometers per hour, the power output is steady but not fast enough when accelerating rapidly, that is, the power comes slowly when accelerating rapidly.

　　Safety: active and passive care.

　　The whole car follows the car’s consistent safety standards and introduces the newly developed driver’s attention warning system, which monitors the driver’s attention level in real time through more than 70 parameters to remind sleepy drivers in time to avoid danger. In addition, the whole car also comes standard with the PRE-SAFE system, intelligent lighting system and 9 airbags (including the newly added driver’s knee airbag). All protection systems work in perfect coordination, which promotes vehicle safety to a new height.

　　More high-strength steel is used in the body structure of the new car, but the kerb quality has not been significantly increased, because the weight and structure have been optimized more scientifically. In addition, in order to ensure that the car has better pedestrian collision performance, its hood can bounce up after being hit hard, so as to better protect the head of the hit pedestrian.

　　New E300 technical parameters

　　Length/width/height (mm): 4872/1854/1454

　　: 3.0 liter V6

　　：7G-TRONIC

　　Maximum power: 170kW/6000rpm

　　Maximum torque: 300 N m/2500-5000 rpm.

　　Suspension: three-link suspension/multi-link independent suspension.

　　

　　The new subsidy policy for new energy vehicles has appropriately raised the threshold of technical indicators, focused on supporting high-quality products with excellent energy consumption and high technical level, and encouraged enterprises to pay attention to safety and consistency.

　　At the same time, the implementation of the New Deal has also accelerated the "reshuffle" of the industry. Low-end enterprises that rely on subsidies for survival are doomed to be eliminated. Only by accelerating innovation drive and improving product strength can new energy vehicle companies hedge the impact of subsidies.

　　The much-anticipated financial subsidy policy for new energy vehicles has finally been introduced. On the 26th, the Ministry of Finance, the Ministry of Industry and Information Technology, the Ministry of Science and Technology and the Development and Reform Commission jointly issued the Notice on Further Improving the Financial Subsidy Policy for the Promotion and Application of New Energy Vehicles, which clarified the subsidy standards and liquidation methods for new energy vehicles in 2019. Compared with the previous subsidy policy, what specific changes will the New Deal have, what impact will it bring to the industry, and how should enterprises respond?

　　Pure electric vehicle compensation is reduced by nearly half

　　In 2019, the New Deal proposed that the driving range of pure electric passenger cars should not be less than 250 kilometers, that of plug-in hybrid passenger cars (including extended range) should not be less than 50 kilometers, and that the subsidized driving range should only be divided into "two grades" of 250 to 400 kilometers and more than 400 kilometers, with subsidy amounts of 18,000 yuan and 25,000 yuan respectively, and that of plug-in hybrid passenger cars (including extended range) should be 10,000 yuan.

　　Last year, except for vehicles below 150km, subsidies for pure electric vehicles were divided into "four gears" with cruising range of 150-200km, 200-250km, 250-300km and 300-400km and above, with subsidies of 15,000 yuan, 24,000 yuan, 34,000 yuan and 45,000 yuan respectively. Plug-in hybrid passenger cars (including increase)

　　"Compared with the previous year, the subsidy for pure electric passenger cars has been reduced by nearly half." Cui Dongshu, Secretary-General of the National Passenger Car Association, said that unlike previous years, when the energy density threshold of the power battery system of new energy vehicles was greatly raised, this policy appropriately raised the threshold of technical indicators according to the principles of advanced technology, reliable quality and guaranteed safety, and kept the upper limit of technical indicators basically unchanged, focusing on supporting high-quality products with excellent energy consumption and high technical level, while encouraging enterprises to pay attention to safety and consistency.

　　Pre-allocation of subsidy funds in time

　　In view of the problem of untimely payment of subsidy funds, the New Deal proposes to improve the liquidation system and improve the efficiency of funds. It is required that from 2019, some funds will be pre-allocated after the vehicles with operating mileage requirements are sold and licensed. After meeting the mileage requirements, they can apply for liquidation according to procedures. After the release of the policy, vehicles with operating mileage requirements will not be subsidized if they run less than 20,000 kilometers within 2 years from the date of registration, and the pre-allocated funds will be deducted at the time of liquidation.

　　It is understood that subsidies for new energy vehicles are divided into central financial subsidies and local financial subsidies. After enterprises submit application documents and materials, the central financial subsidies need to be approved and tested by the National Development and Reform Commission, the Finance Committee, the Ministry of Industry and Information Technology and the Ministry of Finance; Local financial subsidies involve many cities, and the declaration process is also different. Some enterprises report that compared with central financial subsidies, local financial subsidies have many application links and long processes, and the progress of distribution is more difficult to determine.

　　"If there is no cash flow and financing is difficult, it will affect the bank’s guarantee and mortgage. The superposition of layers will increase the investment cost of car companies and bring some pressure to the operation of upstream batteries and other enterprises." Cui Dongshu said that new energy vehicle enterprises themselves need cash flow, and this subsidy policy clarifies the rules for timely payment of subsidy funds, so that enterprises can research and develop and promote the market with peace of mind, thus achieving sustainable development.

　　Local financial withdrawal subsidy

　　The new policy also clearly states that local governments should improve their policies. After the transition period, they will no longer give purchase subsidies to new energy vehicles (except new energy buses and fuel cell vehicles), and instead use them to support the "short board" construction of charging (hydrogenation) infrastructure and supporting operational services. If the local government continues to grant purchase subsidies, the central government will deduct the relevant financial subsidies accordingly.

　　"This means that local finance will withdraw its subsidies to vehicle manufacturers, and the policy based on financial subsidies will shift more to the non-financial system, focusing on optimizing the development environment of new energy vehicles, including road rights, charging facilities, power battery recycling, commercial insurance, used cars and so on. At the same time, it also helps to reduce local protectionism. " Cui Dongshu said that China’s policy of encouraging the development of new energy vehicles is a systematic policy, aiming at realizing the joint support system of national and local new energy vehicle policies, ensuring that after the subsidy is completely withdrawn in 2021, new energy vehicle products still have certain advantages over the policy environment of traditional fuel vehicles, and promoting the establishment of a market-oriented independent new energy vehicle selection system.

　　In addition, the transitional policy also allows car companies to have a reasonable layout and time period for calibrating new products.

　　The influence of the New Deal has different reactions.

　　"The intensity of this slope retreat is expected, and the impact on enterprises is not too great." Zhao Changjiang, general manager of BYD Auto Sales Co., Ltd. said that only by accelerating innovation drive and enhancing product strength can enterprises better hedge the impact of subsidy retreat.

　　However, many people in the industry said that with the increase of subsidies, many uncertainties have been added to the original high-speed development of new energy vehicles. Chen Hong, chairman of SAIC, bluntly said that without subsidies, China’s new energy vehicle market would decline significantly.

　　"After the subsidy for new energy vehicles has declined, car companies can ‘ Complement ’ 。” Jia Xinguang, executive director of china automobile dealers association, pointed out that the power battery occupies a very important position in the manufacturing cost of new energy vehicles. If the battery cost can be reduced through technological innovation, the impact of subsidy retreat on the market will be weakened.

　　"It is not necessarily a good thing for a powerful enterprise. Subsidies should be seen dialectically." Gu Huinan, general manager of GAC New Energy, told reporters that with the gradual withdrawal of financial subsidies, the reshuffle of new energy vehicles is coming, and those low-end enterprises that rely on subsidies for survival are doomed to be eliminated. What can stand out must be the outstanding enterprises that actively face the market and can provide products with market competitiveness.

Original DY MedSci Metz

Lead: spoiler of folic acid new consensus.

Medical news today

On September 5th, the conference of "Consensus of Multidisciplinary Experts on Reasonable Clinical Folic Acid Supplement in China" was successfully held in Beijing. After being checked by authoritative experts, the consensus gives personalized and detailed folic acid supplementation suggestions to the general population and the special population according to different physiological stages.

Folic acid is a water-soluble B vitamin, which naturally exists in some foods, can also be added to other foods, and can be used as a dietary supplement. "Folic acid" used to be called "folic acid protein", sometimes also called "vitamin B9", which is a general term for naturally occurring food folic acid and folic acid in dietary supplements and fortified foods. Food folic acid is in the form of tetrahydrofolic acid (THF), which usually has other glutamic acid residues, making it a polyglutamate. Some dietary supplements also contain 5-methyl -THF (also known as L-5-MTHF, 5-MTHF, L- methyl folic acid or methyl folic acid) in the form of monosodium glutamate.

Folate, wiki

Folic acid helps to form DNA and RNA, and participates in protein metabolism. It plays a key role in the decomposition of homocysteine, which is an amino acid. If the content is too high, it will have harmful effects on human body. Folic acid is also needed to produce healthy red blood cells. Folic acid is very important in the period of rapid human growth, such as pregnancy and fetal development. Therefore, folic acid deficiency is closely related to the occurrence and development of many diseases, such as neonatal neural tube defects (NTDs), various pregnancy damages (abortion, premature delivery, etc.), hypertension, stroke, abnormal mental behavior and other cognitive disorders.

Who is short of folic acid?

The following situations may increase people’s risk of folic acid deficiency:

1. drinking too much. Alcohol will interfere with the absorption of folic acid and accelerate the decomposition of folic acid. In addition, alcoholics tend to eat inferior diets with low folic acid content, which increases the risk of folic acid deficiency in this group of people.

2. Pregnancy. Because folic acid plays an important role in fetal cell development, the demand for folic acid will increase during pregnancy.

3. Intestinal surgery or digestive system diseases. Surgery involving digestive organs or lowering normal gastric acid levels may affect folic acid absorption. Celiac disease and inflammatory bowel disease can also reduce the absorption of folic acid. Studies show that about 20%-60% of patients with inflammatory bowel disease suffer from folic acid deficiency.

4. Genetic variation. People with MTHFR gene mutation can not convert folic acid into its active form, which accounts for about 29% of Hispanic population, 10% of Caucasians and Asians, and 1% of African-Americans.

Lack of folic acid may lead to anemia, weakness and fatigue; Irregular heartbeat; Shortness of breath; It is difficult to concentrate; Hair loss; Pale skin; Symptoms such as aphtha.

How do the general population supplement folic acid?

In fact, folic acid deficiency is rare, but some people may be in marginal folic acid state. Folic acid can’t be synthesized in the human body and can only be taken from food. For individuals with folic acid deficiency or deficiency, it is first recommended to supplement folic acid with "food therapy" by improving diet structure. The consensus points out that green leafy vegetables, bean products, animal livers, lean meat and egg yolks are good food sources of folic acid, and chicken livers (1172.2μgDFE/100g), amaranth (419.8μgDFE/100g), pig livers, sheep livers and soybeans are rich in folic acid. Foods with folic acid content ≥ 120 gdfe/100g (solid) or 60μgDFE/100g (liquid) are "high or rich in folic acid", and foods with folic acid content or folic acid source are half. However, if the absorption and utilization rate of natural food is low, the general population should also take measures such as folic acid supplement or fortified food, and the effective and safe dose is 0.4-1mg per day.

Photographing network

However, it should be noted that long-term large-dose (> 1 mg) folic acid supplementation may cause health risks. Studies have shown that taking more folic acid can mask vitamin B12 deficiency. This deficiency most often occurs in the elderly or people who eat vegetarian food, among which B12 deficiency is more common. Folic acid and B12 are both involved in the production of red blood cells, and the shortage of either will lead to anemia. People who take high-dose folic acid supplements may correct anemia and feel better, but B12 deficiency still exists. In this case, if high folic acid intake continues to "mask" the symptoms of B12 deficiency for a long time, it may cause slow but irreversible damage to the brain and nervous system. In addition, long-term folic acid overdose also has the effects of increasing cancer risk, aggravating neurodegenerative diseases, affecting zinc absorption and reducing immunity. Therefore, it is suggested that if natural folic acid is still available every day, folic acid supplements should not be used more than 400μg per day.

How do special people supplement folic acid?

Pregnant women (including pregnant women)

During pregnancy, folic acid demand will increase due to nucleic acid synthesis. Folic acid deficiency during perinatal period will increase the risk of NTDs, leading to birth defects of fetal spine (spina bifida) and brain (anencephaly). Fifty years ago, no one knew what caused these birth defects. Later, two large trials randomly assigned women to take folic acid or placebo, showing that too little folic acid would increase the birth probability of deformed babies, and getting enough folic acid could greatly reduce this incidence.

In addition, folic acid deficiency during pregnancy may also increase the risk of abortion, premature delivery, stillbirth, megaloblastic anemia, pregnancy-induced hypertension, autism spectrum disorder’s offspring and other diseases.

At present, folic acid supplementation for women of childbearing age is a basic policy in China. The incidence of NTDs in China decreased from 27.4/ 10,000 in 1987 to 1.5/ 10,000 in 2017, a decrease of 94.5%.

The blood folic acid level of rural women in northern China is low. The research results show that this group of people can reach the level of preventing NTDs by taking folic acid 0.4mg/d for at least three months. In addition, many studies suggest that increasing dietary folic acid intake can also reduce the risk of NTDs by about 30%-60%.

Therefore, it is suggested by consensus that women should try their best to take food supplements during pregnancy preparation and early pregnancy, and women in the middle and late pregnancy and lactation can take food supplements and folic acid supplements. It is suggested to supplement folic acid 0.4mg/d or 0.8mg/d from the possible pregnancy or at least 3 months before pregnancy until the third month of pregnancy. The intake of folic acid in the second and third trimester of pregnancy should reach 600 gdfe/d, and it is suggested to supplement folic acid with 400 gdfe/d in addition to food supplement. It is recommended to take 550 gdfe/d folic acid during lactation, and it is recommended to supplement 350 gdfe/d folic acid in addition to food supplement. Personalized supplements are needed for people who live in the north, eat less vegetables and fruits, and have low blood folic acid levels. For women with NTDs reproductive history, diseases such as diabetes, and TT genotype at MTHFR677 locus, the consensus also made tailor-made suggestions.

Cardiovascular disease

The increase of Hcy level caused by folic acid deficiency is considered as an independent risk factor for atherosclerosis and cardiovascular and cerebrovascular diseases. Folic acid deficiency Several large-scale randomized trials of B vitamin supplements to reduce homocysteine levels and prevent heart disease and stroke have not found the benefits of folic acid supplementation. These trials have a similar design: adults with a history of heart disease or stroke or at high risk of heart disease are given pills or placebos containing high doses of vitamins B6, B12 and folic acid. Studies have found that taking high doses of three B vitamins can reduce the level of homocysteine, but it does not lead to a decrease in coronary heart disease events.

However, looking at cardiovascular diseases as a whole may mask the potential benefits of at least one B vitamin, and it may be too late to study people with advanced vascular diseases. An analysis of several studies shows that folic acid supplements can reduce the risk of stroke in people who have not yet had a stroke, but they cannot reduce the risk of a second stroke in people who have already had a stroke.

Effect of folic acid supplementation on stroke risk in preset subgroups

Therefore, it is not recommended to use folic acid to prevent cardiovascular diseases, but folic acid supplementation is recommended for cardiovascular high-risk groups and hypertensive patients with HHcy to reduce Hcy levels. In order to reduce the risk of the first stroke, folic acid monotherapy or fixed compound preparation containing folic acid can be used for patients with HHcy with hypertension. Taking 0.8mg folic acid combined with vitamin B12 daily can achieve the best effect of reducing Hcy.

Neurobehavioral disorders

1. autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which is characterized by difficulties in communication and interaction with others, limited interests and repetitive behaviors. More and more evidence shows that folic acid supplementation during pregnancy may reduce the risk of ASD or reduce the increase of ASD risk caused by prenatal exposure to certain drugs and toxic chemicals. The mechanism of these potential benefits is not clear, but it may be related to the role of folic acid in DNA methylation, which in turn will affect neural development.

Some (but not all) observational studies show that there is a correlation between the use of folic acid and/or multivitamin supplements by pregnant women before and/or during pregnancy and the lower risk of ASD in female offspring. A case-control cohort study of 45,300 Israeli children in 2018 showed that the risk of ASD in children was significantly reduced when mothers took folic acid and/or multivitamin supplements before and/or during pregnancy.

Up to now, the evidence shows that there may be a negative correlation between folic acid intake of mothers during pregnancy and the risk of ASD in their offspring, but there is no evidence to support it in large-scale clinical studies. In addition, some studies believe that children with ASD also have different degrees of abnormal folic acid metabolism due to bad eating behavior, so not exceeding folic acid in these children may be beneficial to the treatment of ASD, but there is still a lack of clinical evidence. Therefore, it is recommended that women of childbearing age should be supplemented with 0.8mg/d regularly to reduce the risk of ASD in their offspring.

2. Depression

Nowadays, depressive disorder has become the second disease in China, with a prevalence rate of 3.02%, ranking first in the total burden of various mental diseases. Some studies have shown that folic acid deficiency is related to depression and low response to antidepressants. The mechanism may be related to the involvement of folic acid in the synthesis of neurotransmitters in the brain. In addition, HHcy is related to depression, and folic acid can degrade Hcy.

In a racial diversity study of 2948 Americans aged 15-39, the concentration of folic acid in serum and red blood cells of patients with severe depression was significantly lower than that of patients who had never suffered from depression. Some clinical studies have shown positive results about whether folic acid supplementation may help depression when used with traditional antidepressants. In addition, the guidelines for the treatment of depression revised by the British Psychopharmacology Association in 2015 and the Canadian network for the treatment of depression and anxiety both recommended folic acid as a supplement to the treatment of serotonin reuptake inhibitors for depression. Therefore, the consensus is that folic acid deficiency is related to depression, and low folic acid level is related to low response of antidepressants. It is recommended that patients with depression should be supplemented with folic acid reasonably on the basis of antidepressants, especially serotonin reuptake inhibitors, and the recommended dose is 0.5-2.5 mg/d.

Cognitive dysfunction

Statistics show that there are 178 million elderly people over 60 years old in China, accounting for about 13% of the total population. There are about 50 million people with dementia and cognitive impairment, and the social burden is huge. Most observational studies conducted so far show that there is a positive correlation between HHcy and the incidence of dementia. Scientists hypothesize that the increase of homocysteine level may have negative effects on the brain through various mechanisms, including the death of neurons caused by cerebrovascular ischemia, abnormal deposition of tau kinase activation and inhibition of methylation reaction.

A Dutch study involving 818 subjects aged 50-70 years showed that folic acid supplementation could reduce Hcy concentration by 26%. Although the cognitive function of subjects declined with age, the folic acid group was superior to the placebo group in memory, information processing speed and sensory motor speed.

Although folic acid supplementation can effectively reduce the level of Hcy, and hypercholesterolemia is an independent risk factor for dementia, based on the current evidence-based medical evidence, it cannot be considered that folic acid supplementation can significantly improve cognitive function. Therefore, the consensus points out that people with cognitive impairment should not advocate long-term use of folic acid without evidence of folic acid deficiency. For those with folic acid deficiency, folic acid 0.8 mg/d can be supplemented (grade C evidence).

kidney disease

Chronic kidney disease (CKD) can lead to Hcy excretion disorder, and dietary restriction in such patients can also increase the risk of folic acid deficiency. Can folic acid supplementation delay the progress of CKD? China’s CSPPT study pointed out that compared with simple antihypertensive therapy, folic acid supplementation of 0.8mg/d can reduce the progress of CKD. But foreign studies show negative results. It is speculated that the difference of research conclusions may be related to the different baseline folic acid levels, that is to say, fortified foods have not been used to supplement folic acid in China, so folic acid supplementation may be beneficial to delay the progression of nephropathy for people with low baseline folic acid levels.

The consensus suggests that folic acid should not be routinely used to delay the progress of CKD, but folic acid supplementation (0.8mg/d) should be considered for patients with folic acid deficiency.

In addition, in the field of cancer, some epidemiological studies show that folic acid intake (or status) is inversely related to colorectal cancer and lung cancer. The exact nature of folic acid on carcinogenesis has not been established, but scientists speculate that folic acid may affect cancer development through its role in carbon metabolism, DNA replication and cell division. Evidence also shows that folic acid may play a dual role in the occurrence and development of cancer. That is to say, folic acid may inhibit some types of cancer in the early stage of development, and taking large doses of folic acid after the establishment of precancerous lesions may promote the development and progress of cancer. We need more research to fully understand how folic acid in diet and folic acid supplementation affect cancer risk, and whether their effects vary with exposure time.

In a word, folic acid is firmly listed in the World Health Organization standard list of essential drugs, and it is one of the most effective and safe drugs needed in the basic public health system. The application of folic acid has achieved great success in improving neonatal malformation, and its application prospect in other fields and disciplines is also very promising. With the deepening of future research, scientists will also find and solve more problems and set more precise guidance for personalized folic acid use.

Note: The content of this article is only for promoting consensus and popular science, and it is not intended to provide personal medical advice.

references

1.Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation.DOI: 10.1056/NEJM199212243272602.

2.Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study.DOI:https://doi.org/10.1016/0140-6736(91)90133-A.

3.Effects of Homocysteine-Lowering With Folic Acid Plus Vitamin B12 vs Placebo on Mortality and Major Morbidity in Myocardial Infarction Survivors.doi:10.1001/jama.2010.840.

4.B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial.DOI:https://doi.org/10.1016/S1474-4422(10)70187-3.

5.Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention.https://doi.org/10.1161/STROKEAHA.109.573410.

6.Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring.JAMA Psychiatry. 2018; 75(2):176-184. doi:10.1001/jamapsychiatry.2017.4050.

7.Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.DOI:https://doi.org/10.1016/S0140-6736(07)60109-3.

8. Information on the conference of China Multidisciplinary Expert Consensus on Reasonable Clinical Folic Acid Supplement.

Source: Metz Medical Comprehensive Report

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